BLT2, a leukotriene B4 receptor 2, as a novel prognostic biomarker of triple-negative breast cancer

Jae In Park, Jae Hyun Jang, Geun Soo Park, Yunro Chung, Hye Jin You, Jae Hong Kim

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

Triple-negative breast cancer (TNBC) is considered to be a notorious type of cancer due to its aggressive metastatic potential and poor prognosis. Recent evidence suggests that BLT2, a low-affinity LTB4 receptor is critically associated with the phenotypes of TNBC cells, including invasion, metastasis, and survival. Furthermore, in a group of 545 breast cancer patients with metastasis, we observed that the high-BLT2 subgroup had a lower disease-free-survival rate than the low-BLT2 subgroup. Thus, we theorized that anti-BLT2 strategies could facilitate the development of new therapies used for TNBC. This review focuses on recent discoveries regarding BLT2 and its roles in as a novel prognostic biomarker in TNBC.

Original languageEnglish
Pages (from-to)373-377
Number of pages5
JournalBMB reports
Volume51
Issue number8
DOIs
Publication statusPublished - 2018

Bibliographical note

Funding Information:
This research was supported by Bio & Medical Technology Development Program Grants (2017M3A9D8063317) and a Mid-Career Researcher Program grant (2017R1A2B4002203) provided by the National Research (NRF) funded by the Ministry of Science, Information and Communication Technologies (ICT), and Future Planning, Republic of Korea. Additionally, this research was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A101032), National Research Foundation of Korea Grant funded by the Korea Government (MSIP, South Korea) (No.2015R1A2A2A01003829) and was also supported by a Korea University grant and the BK21 Plus Program (School of Life Sciences and Biotechnology, Korea University).

Publisher Copyright:
© 2018 by the The Korean Society for Biochemistry and Molecular Biology.

Keywords

  • BLT2
  • Leukotriene B4 receptor-2
  • TNBC
  • Triple-negative breast cancer

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Fingerprint

Dive into the research topics of 'BLT2, a leukotriene B4 receptor 2, as a novel prognostic biomarker of triple-negative breast cancer'. Together they form a unique fingerprint.

Cite this