BODIPY-Coumarin Conjugate as an Endoplasmic Reticulum Membrane Fluidity Sensor and Its Application to ER Stress Models

Hoyeon Lee; Zhigang Yang; Youngjin Wi; Tae Woo Kim; Peter Verwilst; Yun Hak Lee; Ga In Han; Chulhun Kang; Jong Seung Kim

doi:10.1021/acs.bioconjchem.5b00508

BODIPY-Coumarin Conjugate as an Endoplasmic Reticulum Membrane Fluidity Sensor and Its Application to ER Stress Models

Hoyeon Lee, Zhigang Yang, Youngjin Wi, Tae Woo Kim, Peter Verwilst, Yun Hak Lee, Ga In Han, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

An endoplasmic reticulum (ER) membrane-selective chemosensor composed of BODIPY and coumarin moieties and a long alkyl chain (n-C18) was synthesized. The emission ratio of BODIPY to coumarin depends on the solution viscosity. The probe is localized to the ER membrane and was applied to reveal the reduced ER membrane fluidity under ER stress conditions.

Original language	English
Pages (from-to)	2474-2480
Number of pages	7
Journal	Bioconjugate Chemistry
Volume	26
Issue number	12
DOIs	https://doi.org/10.1021/acs.bioconjchem.5b00508
Publication status	Published - 2015 Dec 16

Bibliographical note

Publisher Copyright:
© 2015 American Chemical Society.

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering
Pharmacology
Pharmaceutical Science
Organic Chemistry

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AU - Lee, Hoyeon

AU - Yang, Zhigang

AU - Wi, Youngjin

AU - Kim, Tae Woo

AU - Verwilst, Peter

AU - Lee, Yun Hak

AU - Han, Ga In

AU - Kang, Chulhun

AU - Kim, Jong Seung

PY - 2015/12/16

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AB - An endoplasmic reticulum (ER) membrane-selective chemosensor composed of BODIPY and coumarin moieties and a long alkyl chain (n-C18) was synthesized. The emission ratio of BODIPY to coumarin depends on the solution viscosity. The probe is localized to the ER membrane and was applied to reveal the reduced ER membrane fluidity under ER stress conditions.

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BODIPY-Coumarin Conjugate as an Endoplasmic Reticulum Membrane Fluidity Sensor and Its Application to ER Stress Models

Abstract

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