We synthesized a boron-dipyrromethene (BODIPY)/Nile Red hybrid probe capable of selectively recognizing fluidity changes in the endoplasmic reticulum (ER) membrane due to its preferential localization to the ER and strong energy transfer from BODIPY to the Nile Red moiety, emitting only in nonaqueous environments. ER membrane fluidity in HepG2 cells was markedly reduced by a cell model of metabolic syndrome.
Bibliographical noteFunding Information:
This work was supported by NRF (No. 2014R1A2A1A11052325, CK), (No. 2013R1A1A2065643, TWK), and CRI (No. 2009- 0081566, JSK) project grants from the National Research Foundation of Korea. PV is supported by a Korea University grant.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
- endoplasmic reticulum
- membrane fluidity
- metabolic syndrome
ASJC Scopus subject areas
- Organic Chemistry