Abstract
We synthesized a boron-dipyrromethene (BODIPY)/Nile Red hybrid probe capable of selectively recognizing fluidity changes in the endoplasmic reticulum (ER) membrane due to its preferential localization to the ER and strong energy transfer from BODIPY to the Nile Red moiety, emitting only in nonaqueous environments. ER membrane fluidity in HepG2 cells was markedly reduced by a cell model of metabolic syndrome.
Original language | English |
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Pages (from-to) | 527-531 |
Number of pages | 5 |
Journal | Chemistry - An Asian Journal |
Volume | 11 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2016 Feb 18 |
Keywords
- FRET
- endoplasmic reticulum
- fluorescence
- membrane fluidity
- metabolic syndrome
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry