BODIPY/Nile-Red-Based Efficient FRET Pair: Selective Assay of Endoplasmic Reticulum Membrane Fluidity

Zhigang Yang, Youngjin Wi, Young Min Yoon, Peter Verwilst, Joo Hee Jang, Tae Woo Kim, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


We synthesized a boron-dipyrromethene (BODIPY)/Nile Red hybrid probe capable of selectively recognizing fluidity changes in the endoplasmic reticulum (ER) membrane due to its preferential localization to the ER and strong energy transfer from BODIPY to the Nile Red moiety, emitting only in nonaqueous environments. ER membrane fluidity in HepG2 cells was markedly reduced by a cell model of metabolic syndrome.

Original languageEnglish
Pages (from-to)527-531
Number of pages5
JournalChemistry - An Asian Journal
Issue number4
Publication statusPublished - 2016 Feb 18

Bibliographical note

Funding Information:
This work was supported by NRF (No. 2014R1A2A1A11052325, CK), (No. 2013R1A1A2065643, TWK), and CRI (No. 2009- 0081566, JSK) project grants from the National Research Foundation of Korea. PV is supported by a Korea University grant.

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


  • FRET
  • endoplasmic reticulum
  • fluorescence
  • membrane fluidity
  • metabolic syndrome

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry


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