Bone morphogenic protein-2 (BMP-2) loaded hybrid coating on porous hydroxyapatite scaffolds for bone tissue engineering

Shin Hee Jun, Eun Jung Lee, Tae Sik Jang, Hyoun Ee Kim, Jun Hyeog Jang, Young Hag Koh

Research output: Contribution to journalArticlepeer-review

78 Citations (Scopus)


In this study, a silica xerogel-chitosan hybrid is utilized as a coating material to incorporate bone morphogenic protein-2 (BMP-2) on a porous hydroxyapatite (HA) scaffold for bone tissue engineering. BMP-2 is known as a therapeutic agent for improving bone regeneration and repair. Silica xerogel-chitosan hybrids have been used for the delivery of a growth factor as well as osteoconductive coatings. The biological properties of the hybrid coating incorporated with BMP-2 were evaluated in terms of the BMP-2 release behavior, osteoblastic cellular responses and in vivo performance. BMP-2 was continuously released from the hybrid coating layer on the porous HA scaffold for up to 6 weeks. The hybrid coating containing BMP-2 showed significantly enhanced osteoblastic cell responses in comparison with the hybrid coating and HA substrate. Consequently, new bone formation was significantly increased within the hybrid coating containing BMP-2. These results reveal that the hybrid coating containing BMP-2 has the potential to be used as a bone implant, whose osteogenic properties are promoted by the release of BMP-2 in a controlled manner for a prolonged period of time.

Original languageEnglish
Pages (from-to)773-782
Number of pages10
JournalJournal of Materials Science: Materials in Medicine
Issue number3
Publication statusPublished - 2013 Mar

Bibliographical note

Funding Information:
Acknowledgments This research was supported by World Class University (WCU) project through National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (R31-2008-000-10075-0) and by the Technology Innovation Program (Contract No. 10037915, WPM Biomedical Materials—Implant Materials) funded by the Ministry of Knowledge Economy (MKE, Korea).

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


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