Bone-protective effects of Lactobacillus plantarum B719-fermented milk product

Chul Sang Lee, Sun Ho Lee, Sae Hun Kim

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


The current study aimed to investigate the anti-osteoporotic effects of a Lactobacillus plantarum B719-fermented milk product (FMP-B719). Higher proliferation and mineralisation were observed in FMP-B719-treated MC3T3-E1 mouse pre-osteoblastic cells than those in L. casei ATCC 393-FMP-treated MC3T3-E1 cells. Moreover, FMP-B719 normalised the serum alkaline phosphatase (9.37 ± 1.92 U/L) and phosphorus (8.28 ± 0.1 mg/dL) in a rat model of ovariectomy-induced postmenopausal osteoporosis. Furthermore, FMP-B719 normalized the bone volume in the proximal femur and increased the femur strength that was decreased in ovariectomized rats. Hence, the results of this study suggest that FMP-B719 could serve as a potential candidate for the treatment and prevention of postmenopausal osteoporosis.

Original languageEnglish
Pages (from-to)706-717
Number of pages12
JournalInternational Journal of Dairy Technology
Issue number4
Publication statusPublished - 2020 Nov 1

Bibliographical note

Funding Information:
This work was supported by the HighValue-Added Food Technology Development Program of the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (iPET), and the Ministry for Food, Agriculture, Forestry and Fisheries of Republic of Korea (117051-03-1-HD020) and Institute of Animal Molecular Biotechnology Grant. [Correction added on 23 June 2020, after first online publication: The Acknowledgement section has been updated in this version.]

Publisher Copyright:
© 2020 Society of Dairy Technology


  • Fermented milk
  • Lactic acid bacteria
  • Lactobacillus
  • Microbiology
  • Probiotics

ASJC Scopus subject areas

  • Food Science
  • Bioengineering
  • Process Chemistry and Technology


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