Bone-protective effects of Lactobacillus plantarum B719-fermented milk product

Chul Sang Lee; Sun Ho Lee; Sae Hun Kim

doi:10.1111/1471-0307.12701

Bone-protective effects of Lactobacillus plantarum B719-fermented milk product

Chul Sang Lee, Sun Ho Lee, Sae Hun Kim

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

The current study aimed to investigate the anti-osteoporotic effects of a Lactobacillus plantarum B719-fermented milk product (FMP-B719). Higher proliferation and mineralisation were observed in FMP-B719-treated MC3T3-E1 mouse pre-osteoblastic cells than those in L. casei ATCC 393-FMP-treated MC3T3-E1 cells. Moreover, FMP-B719 normalised the serum alkaline phosphatase (9.37 ± 1.92 U/L) and phosphorus (8.28 ± 0.1 mg/dL) in a rat model of ovariectomy-induced postmenopausal osteoporosis. Furthermore, FMP-B719 normalized the bone volume in the proximal femur and increased the femur strength that was decreased in ovariectomized rats. Hence, the results of this study suggest that FMP-B719 could serve as a potential candidate for the treatment and prevention of postmenopausal osteoporosis.

Original language	English
Pages (from-to)	706-717
Number of pages	12
Journal	International Journal of Dairy Technology
Volume	73
Issue number	4
DOIs	https://doi.org/10.1111/1471-0307.12701
Publication status	Published - 2020 Nov 1

Keywords

Fermented milk
Lactic acid bacteria
Lactobacillus
Microbiology
Probiotics

ASJC Scopus subject areas

Food Science
Bioengineering
Process Chemistry and Technology

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10.1111/1471-0307.12701

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title = "Bone-protective effects of Lactobacillus plantarum B719-fermented milk product",

abstract = "The current study aimed to investigate the anti-osteoporotic effects of a Lactobacillus plantarum B719-fermented milk product (FMP-B719). Higher proliferation and mineralisation were observed in FMP-B719-treated MC3T3-E1 mouse pre-osteoblastic cells than those in L. casei ATCC 393-FMP-treated MC3T3-E1 cells. Moreover, FMP-B719 normalised the serum alkaline phosphatase (9.37 ± 1.92 U/L) and phosphorus (8.28 ± 0.1 mg/dL) in a rat model of ovariectomy-induced postmenopausal osteoporosis. Furthermore, FMP-B719 normalized the bone volume in the proximal femur and increased the femur strength that was decreased in ovariectomized rats. Hence, the results of this study suggest that FMP-B719 could serve as a potential candidate for the treatment and prevention of postmenopausal osteoporosis.",

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author = "Lee, {Chul Sang} and Lee, {Sun Ho} and Kim, {Sae Hun}",

note = "Funding Information: This work was supported by the HighValue-Added Food Technology Development Program of the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (iPET), and the Ministry for Food, Agriculture, Forestry and Fisheries of Republic of Korea (117051-03-1-HD020) and Institute of Animal Molecular Biotechnology Grant. [Correction added on 23 June 2020, after first online publication: The Acknowledgement section has been updated in this version.] Publisher Copyright: {\textcopyright} 2020 Society of Dairy Technology",

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N2 - The current study aimed to investigate the anti-osteoporotic effects of a Lactobacillus plantarum B719-fermented milk product (FMP-B719). Higher proliferation and mineralisation were observed in FMP-B719-treated MC3T3-E1 mouse pre-osteoblastic cells than those in L. casei ATCC 393-FMP-treated MC3T3-E1 cells. Moreover, FMP-B719 normalised the serum alkaline phosphatase (9.37 ± 1.92 U/L) and phosphorus (8.28 ± 0.1 mg/dL) in a rat model of ovariectomy-induced postmenopausal osteoporosis. Furthermore, FMP-B719 normalized the bone volume in the proximal femur and increased the femur strength that was decreased in ovariectomized rats. Hence, the results of this study suggest that FMP-B719 could serve as a potential candidate for the treatment and prevention of postmenopausal osteoporosis.

AB - The current study aimed to investigate the anti-osteoporotic effects of a Lactobacillus plantarum B719-fermented milk product (FMP-B719). Higher proliferation and mineralisation were observed in FMP-B719-treated MC3T3-E1 mouse pre-osteoblastic cells than those in L. casei ATCC 393-FMP-treated MC3T3-E1 cells. Moreover, FMP-B719 normalised the serum alkaline phosphatase (9.37 ± 1.92 U/L) and phosphorus (8.28 ± 0.1 mg/dL) in a rat model of ovariectomy-induced postmenopausal osteoporosis. Furthermore, FMP-B719 normalized the bone volume in the proximal femur and increased the femur strength that was decreased in ovariectomized rats. Hence, the results of this study suggest that FMP-B719 could serve as a potential candidate for the treatment and prevention of postmenopausal osteoporosis.

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Bone-protective effects of Lactobacillus plantarum B719-fermented milk product

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Keywords

ASJC Scopus subject areas

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