Bone-protective effects of Lactobacillus plantarum B719-fermented milk product

Chul Sang Lee, Sun Ho Lee, Sae Hun Kim

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


The current study aimed to investigate the anti-osteoporotic effects of a Lactobacillus plantarum B719-fermented milk product (FMP-B719). Higher proliferation and mineralisation were observed in FMP-B719-treated MC3T3-E1 mouse pre-osteoblastic cells than those in L. casei ATCC 393-FMP-treated MC3T3-E1 cells. Moreover, FMP-B719 normalised the serum alkaline phosphatase (9.37 ± 1.92 U/L) and phosphorus (8.28 ± 0.1 mg/dL) in a rat model of ovariectomy-induced postmenopausal osteoporosis. Furthermore, FMP-B719 normalized the bone volume in the proximal femur and increased the femur strength that was decreased in ovariectomized rats. Hence, the results of this study suggest that FMP-B719 could serve as a potential candidate for the treatment and prevention of postmenopausal osteoporosis.

Original languageEnglish
Pages (from-to)706-717
Number of pages12
JournalInternational Journal of Dairy Technology
Issue number4
Publication statusPublished - 2020 Nov 1


  • Fermented milk
  • Lactic acid bacteria
  • Lactobacillus
  • Microbiology
  • Probiotics

ASJC Scopus subject areas

  • Food Science
  • Bioengineering
  • Process Chemistry and Technology


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