Borna disease virus and deficit schizophrenia

Yong Ku Kim; Sang Hyun Kim; Chang Su Han; Heon Jeong Lee; Hyung Seob Kim; Sung Chul Yoon; Dai Jin Kim; Ki Joon Song; Michael Maes; Jin Won Song

doi:10.1034/j.1601-5215.2003.00043.x

Borna disease virus and deficit schizophrenia

Yong Ku Kim, Sang Hyun Kim, Chang Su Han, Heon Jeong Lee, Hyung Seob Kim, Sung Chul Yoon, Dai Jin Kim, Ki Joon Song, Michael Maes, Jin Won Song

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Background: It is controversial whether Borna disease virus (BDV) infects humans and causes psychiatric disorders. Objectives: The relationship between BDV infection and schizophrenia with deficit syndrome was investigated. Study design: Using the Schedule for the Deficit Syndrome, 62 schizophrenic in-patients were selected from three psychiatric hospitals. RNA was extracted from peripheral blood mononuclear cells and analyzed using nested reverse transcriptase-polymerase chain reaction with primers to detect BDV p24 and p40. Results and conclusions: BDV transcripts were not detected in samples from any of the 62 schizophrenic patients. These data do not support an etiologic association between BDV infection and the deficit form of schizophrenia.

Original language	English
Pages (from-to)	262-265
Number of pages	4
Journal	Acta Neuropsychiatrica
Volume	15
Issue number	5
DOIs	https://doi.org/10.1034/j.1601-5215.2003.00043.x
Publication status	Published - 2003 Oct

Keywords

Borna disease virus
Deficit syndrome
PBMC
RT-PCR
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1034/j.1601-5215.2003.00043.x

Cite this

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title = "Borna disease virus and deficit schizophrenia",

abstract = "Background: It is controversial whether Borna disease virus (BDV) infects humans and causes psychiatric disorders. Objectives: The relationship between BDV infection and schizophrenia with deficit syndrome was investigated. Study design: Using the Schedule for the Deficit Syndrome, 62 schizophrenic in-patients were selected from three psychiatric hospitals. RNA was extracted from peripheral blood mononuclear cells and analyzed using nested reverse transcriptase-polymerase chain reaction with primers to detect BDV p24 and p40. Results and conclusions: BDV transcripts were not detected in samples from any of the 62 schizophrenic patients. These data do not support an etiologic association between BDV infection and the deficit form of schizophrenia.",

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author = "Kim, {Yong Ku} and Kim, {Sang Hyun} and Han, {Chang Su} and Lee, {Heon Jeong} and Kim, {Hyung Seob} and Yoon, {Sung Chul} and Kim, {Dai Jin} and Song, {Ki Joon} and Michael Maes and Song, {Jin Won}",

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T1 - Borna disease virus and deficit schizophrenia

AU - Kim, Yong Ku

AU - Kim, Sang Hyun

AU - Han, Chang Su

AU - Lee, Heon Jeong

AU - Kim, Hyung Seob

AU - Yoon, Sung Chul

AU - Kim, Dai Jin

AU - Song, Ki Joon

AU - Maes, Michael

AU - Song, Jin Won

PY - 2003/10

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AB - Background: It is controversial whether Borna disease virus (BDV) infects humans and causes psychiatric disorders. Objectives: The relationship between BDV infection and schizophrenia with deficit syndrome was investigated. Study design: Using the Schedule for the Deficit Syndrome, 62 schizophrenic in-patients were selected from three psychiatric hospitals. RNA was extracted from peripheral blood mononuclear cells and analyzed using nested reverse transcriptase-polymerase chain reaction with primers to detect BDV p24 and p40. Results and conclusions: BDV transcripts were not detected in samples from any of the 62 schizophrenic patients. These data do not support an etiologic association between BDV infection and the deficit form of schizophrenia.

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KW - Deficit syndrome

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KW - RT-PCR

KW - Schizophrenia

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Borna disease virus and deficit schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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