TY - JOUR
T1 - Brachial-ankle pulse wave velocity is associated with coronary calcification among 1131 healthy middle-aged men
AU - Vishnu, Abhishek
AU - Choo, Jina
AU - Wilcox, Bradley
AU - Hisamatsu, Takashi
AU - Barinas-Mitchell, Emma J.M.
AU - Fujiyoshi, Akira
AU - Mackey, Rachel H.
AU - Kadota, Aya
AU - Ahuja, Vasudha
AU - Kadowaki, Takashi
AU - Edmundowicz, Daniel
AU - Miura, Katsuyuki
AU - Rodriguez, Beatriz L.
AU - Kuller, Lewis H.
AU - Shin, Chol
AU - Masaki, Kamal
AU - Ueshima, Hirotsugu
AU - Sekikawa, Akira
N1 - Publisher Copyright:
© 2015 Elsevier Ireland Ltd. All rights reserved.
PY - 2015/6/15
Y1 - 2015/6/15
N2 - Background: Brachial-ankle pulse wave velocity (baPWV) is a simple and reproducible measure of arterial stiffness and is extensively used to assess cardiovascular disease (CVD) risk in eastern Asia. We examined whether baPWV is associated with coronary atherosclerosis in an international study of healthy middle-aged men. Methods: A population-based sample of1131 men aged 40-49 years was recruited - 257 Whites and 75 Blacks in Pittsburgh, US, 228 Japanese-Americans in Honolulu, US, 292 Japanese in Otsu, Japan, and 279 Koreans in Ansan, Korea. baPWV was measured with an automated waveform analyzer (VP2000, Omron) and atherosclerosis was examined as coronary artery calcification (CAC) by computed-tomography (GE-Imatron EBT scanner). Association of the presence of CAC (defined as ≥10 Agatston unit) was examined with continuous measure as well as with increasing quartiles of baPWV. Results: As compared to the lowest quartile of baPWV, the multivariable-adjusted odds ratio (95% Confidence Interval [CI]) for the presence of CAC in the combined sample was 1.70 (0.98, 2.94) for 2nd quartile, 1.88 (1.08, 3.28) for 3rd quartile, and 2.16 (1.19, 3.94) for 4th quartile (p-trend = 0.01). The odds for CAC increased by 19% per 100 cm/s increase (p < 0.01), or by 36% per standard-deviation increase (p < 0.01) in baPWV. Similar effect-sizes were observed in individual races, and were significant among Whites, Blacks and Koreans. Conclusion: baPWV is cross-sectionally associated with CAC among healthy middle-aged men. The association was significant in Whites and Blacksin the US, and among Koreans. Longitudinal studies are needed to determine its CVD predictive ability.
AB - Background: Brachial-ankle pulse wave velocity (baPWV) is a simple and reproducible measure of arterial stiffness and is extensively used to assess cardiovascular disease (CVD) risk in eastern Asia. We examined whether baPWV is associated with coronary atherosclerosis in an international study of healthy middle-aged men. Methods: A population-based sample of1131 men aged 40-49 years was recruited - 257 Whites and 75 Blacks in Pittsburgh, US, 228 Japanese-Americans in Honolulu, US, 292 Japanese in Otsu, Japan, and 279 Koreans in Ansan, Korea. baPWV was measured with an automated waveform analyzer (VP2000, Omron) and atherosclerosis was examined as coronary artery calcification (CAC) by computed-tomography (GE-Imatron EBT scanner). Association of the presence of CAC (defined as ≥10 Agatston unit) was examined with continuous measure as well as with increasing quartiles of baPWV. Results: As compared to the lowest quartile of baPWV, the multivariable-adjusted odds ratio (95% Confidence Interval [CI]) for the presence of CAC in the combined sample was 1.70 (0.98, 2.94) for 2nd quartile, 1.88 (1.08, 3.28) for 3rd quartile, and 2.16 (1.19, 3.94) for 4th quartile (p-trend = 0.01). The odds for CAC increased by 19% per 100 cm/s increase (p < 0.01), or by 36% per standard-deviation increase (p < 0.01) in baPWV. Similar effect-sizes were observed in individual races, and were significant among Whites, Blacks and Koreans. Conclusion: baPWV is cross-sectionally associated with CAC among healthy middle-aged men. The association was significant in Whites and Blacksin the US, and among Koreans. Longitudinal studies are needed to determine its CVD predictive ability.
KW - Arteriosclerosis
KW - Atherosclerosis
KW - Pulse wave analysis
KW - Vascular calcification
KW - Vascular stiffness
UR - http://www.scopus.com/inward/record.url?scp=84929155473&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2015.04.020
DO - 10.1016/j.ijcard.2015.04.020
M3 - Article
C2 - 25885874
AN - SCOPUS:84929155473
SN - 0167-5273
VL - 189
SP - 67
EP - 72
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 1
ER -
