Brachial-ankle pulse wave velocity is associated with coronary calcification among 1131 healthy middle-aged men

Abhishek Vishnu, Jina Choo, Bradley Wilcox, Takashi Hisamatsu, Emma J.M. Barinas-Mitchell, Akira Fujiyoshi, Rachel H. Mackey, Aya Kadota, Vasudha Ahuja, Takashi Kadowaki, Daniel Edmundowicz, Katsuyuki Miura, Beatriz L. Rodriguez, Lewis H. Kuller, Chol Shin, Kamal Masaki, Hirotsugu Ueshima, Akira Sekikawa

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23 Citations (Scopus)


Background: Brachial-ankle pulse wave velocity (baPWV) is a simple and reproducible measure of arterial stiffness and is extensively used to assess cardiovascular disease (CVD) risk in eastern Asia. We examined whether baPWV is associated with coronary atherosclerosis in an international study of healthy middle-aged men. Methods: A population-based sample of1131 men aged 40-49 years was recruited - 257 Whites and 75 Blacks in Pittsburgh, US, 228 Japanese-Americans in Honolulu, US, 292 Japanese in Otsu, Japan, and 279 Koreans in Ansan, Korea. baPWV was measured with an automated waveform analyzer (VP2000, Omron) and atherosclerosis was examined as coronary artery calcification (CAC) by computed-tomography (GE-Imatron EBT scanner). Association of the presence of CAC (defined as ≥10 Agatston unit) was examined with continuous measure as well as with increasing quartiles of baPWV. Results: As compared to the lowest quartile of baPWV, the multivariable-adjusted odds ratio (95% Confidence Interval [CI]) for the presence of CAC in the combined sample was 1.70 (0.98, 2.94) for 2nd quartile, 1.88 (1.08, 3.28) for 3rd quartile, and 2.16 (1.19, 3.94) for 4th quartile (p-trend = 0.01). The odds for CAC increased by 19% per 100 cm/s increase (p < 0.01), or by 36% per standard-deviation increase (p < 0.01) in baPWV. Similar effect-sizes were observed in individual races, and were significant among Whites, Blacks and Koreans. Conclusion: baPWV is cross-sectionally associated with CAC among healthy middle-aged men. The association was significant in Whites and Blacksin the US, and among Koreans. Longitudinal studies are needed to determine its CVD predictive ability.

Original languageEnglish
Pages (from-to)67-72
Number of pages6
JournalInternational Journal of Cardiology
Issue number1
Publication statusPublished - 2015 Jun 15

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Ireland Ltd. All rights reserved.


  • Arteriosclerosis
  • Atherosclerosis
  • Pulse wave analysis
  • Vascular calcification
  • Vascular stiffness

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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