Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia

Jieun Shin; Hawon Cho; Sun Wook Hwang; Jooyoung Jung; Chan Young Shin; Soon Youl Lee; So Hee Kim; Myung Gull Lee; Young Hae Choi; Jinwoong Kim; Nicole Alessandri Haber; David B. Reichling; Sachia Khasar; Jon D. Levine; Uhtaek Oh

doi:10.1073/pnas.152002699

Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia

Jieun Shin, Hawon Cho, Sun Wook Hwang, Jooyoung Jung, Chan Young Shin, Soon Youl Lee, So Hee Kim, Myung Gull Lee, Young Hae Choi, Jinwoong Kim, Nicole Alessandri Haber, David B. Reichling, Sachia Khasar, Jon D. Levine, Uhtaek Oh

Research output: Contribution to journal › Article › peer-review

326 Citations (Scopus)

Abstract

The capsaicin-sensitive vanilloid receptor (VR1) was recently shown to play an important role in inflammatory pain (hyperalgesia), but the underlying mechanism is unknown. We hypothesized that pain-producing inflammatory mediators activate capsaicin receptors by inducing the production of fatty acid agonists of VR1. This study demonstrates that bradykinin, acting at B2 bradykinin receptors, excites sensory nerve endings by activating capsaicin receptors via production of 12-lipoxygenase metabolites of arachidonic acid. This finding identifies a mechanism that might be targeted in the development of new therapeutic strategies for the treatment of inflammatory pain.

Original language	English
Pages (from-to)	10150-10155
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	99
Issue number	15
DOIs	https://doi.org/10.1073/pnas.152002699
Publication status	Published - 2002 Jul 23
Externally published	Yes

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Shin, J., Cho, H., Hwang, S. W., Jung, J., Shin, C. Y., Lee, S. Y., Kim, S. H., Lee, M. G., Choi, Y. H., Kim, J., Haber, N. A., Reichling, D. B., Khasar, S., Levine, J. D., & Oh, U. (2002). Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia. Proceedings of the National Academy of Sciences of the United States of America, 99(15), 10150-10155. https://doi.org/10.1073/pnas.152002699

Shin, J, Cho, H, Hwang, SW, Jung, J, Shin, CY, Lee, SY, Kim, SH, Lee, MG, Choi, YH, Kim, J, Haber, NA, Reichling, DB, Khasar, S, Levine, JD & Oh, U 2002, 'Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia', Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 15, pp. 10150-10155. https://doi.org/10.1073/pnas.152002699

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abstract = "The capsaicin-sensitive vanilloid receptor (VR1) was recently shown to play an important role in inflammatory pain (hyperalgesia), but the underlying mechanism is unknown. We hypothesized that pain-producing inflammatory mediators activate capsaicin receptors by inducing the production of fatty acid agonists of VR1. This study demonstrates that bradykinin, acting at B2 bradykinin receptors, excites sensory nerve endings by activating capsaicin receptors via production of 12-lipoxygenase metabolites of arachidonic acid. This finding identifies a mechanism that might be targeted in the development of new therapeutic strategies for the treatment of inflammatory pain.",

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AU - Shin, Chan Young

AU - Lee, Soon Youl

AU - Kim, So Hee

AU - Lee, Myung Gull

AU - Choi, Young Hae

AU - Kim, Jinwoong

AU - Haber, Nicole Alessandri

AU - Reichling, David B.

AU - Khasar, Sachia

AU - Levine, Jon D.

AU - Oh, Uhtaek

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Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia

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