Brain atlas fusion from high-thickness diagnostic magnetic resonance images by learning-based super-resolution

Jinpeng Zhang, Lichi Zhang, Lei Xiang, Yeqin Shao, Guorong Wu, Xiaodong Zhou, Dinggang Shen, Qian Wang

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


It is fundamentally important to fuse the brain atlas from magnetic resonance (MR) images for many imaging-based studies. Most existing works focus on fusing the atlases from high-quality MR images. However, for low-quality diagnostic images (i.e., with high inter-slice thickness), the problem of atlas fusion has not been addressed yet. In this paper, we intend to fuse the brain atlas from the high-thickness diagnostic MR images that are prevalent for clinical routines. The main idea of our works is to extend the conventional groupwise registration by incorporating a novel super-resolution strategy. The contribution of the proposed super-resolution framework is two-fold. First, each high-thickness subject image is reconstructed to be isotropic by the patch-based sparsity learning. Then, the reconstructed isotropic image is enhanced for better quality through the random-forest-based regression model. In this way, the images obtained by the super-resolution strategy can be fused together by applying the groupwise registration method to construct the required atlas. Our experiments have shown that the proposed framework can effectively solve the problem of atlas fusion from the low-quality brain MR images.

Original languageEnglish
Pages (from-to)531-541
Number of pages11
JournalPattern Recognition
Publication statusPublished - 2017 Mar 1

Bibliographical note

Funding Information:
This work is supported by National Institutes of Health (NIH) grants ( EB006733 , EB008374 , MH100217 , MH108914 , AG041721 , AG049371 , AG042599 , AG053867 , EB022880 ), National Natural Science Foundation of China (NSFC) grants ( 61473190 , 61401271 , 81471733 ) and Science and Technology Commission of Shanghai Municipality (STCSM) grants ( 16511101100 , 16410722400 ).

Publisher Copyright:
© 2016 Elsevier Ltd


  • Brain atlas
  • Groupwise registration
  • Image enhancement
  • Random forest regression
  • Sparsity learning
  • Super-resolution

ASJC Scopus subject areas

  • Software
  • Signal Processing
  • Computer Vision and Pattern Recognition
  • Artificial Intelligence


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