Bright light exposure before bedtime impairs response inhibition the following morning: a non-randomized crossover study

Jung Ick Byun; Byeong Uk Lee; Yong Seo Koo; Jun Sang Sunwoo; Jung Ah Lim; Jangsup Moon; Soon Tae Lee; Keun Hwa Jung; Kon Chu; Manho Kim; Jong Min Lim; Heon Jeong Lee; Eunil Lee; Sang Kun Lee; Ki Young Jung

doi:10.1080/07420528.2018.1452030

Bright light exposure before bedtime impairs response inhibition the following morning: a non-randomized crossover study

Jung Ick Byun, Byeong Uk Lee, Yong Seo Koo, Jun Sang Sunwoo, Jung Ah Lim, Jangsup Moon, Soon Tae Lee, Keun Hwa Jung, Kon Chu, Manho Kim, Jong Min Lim, Heon Jeong Lee, Eunil Lee, Sang Kun Lee, Ki Young Jung

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Introduction: Bright light exposure in the late evening can affect cognitive function the following morning either by changing the biological clock and/or disturbing sleep, but the evidence for this effect is scarce, and the underlying mechanism remains unknown. In this study, we first aimed to evaluate the effect of bright light exposure before bedtime on frontal lobe activity the following morning using near-infrared spectroscopy (NIRS) during a Go/NoGo task. Second, we aimed to evaluate the effects of bright light exposure before bedtime on polysomnographic measures and on a frontal lobe function test the following morning. Methods: Twenty healthy, young males (mean age, 25.5 years) were recruited between September 2013 and August 2014. They were first exposed to control light (150 lux) before bedtime (from 20:00 h to 24:00 h) for 2 days and then to bright light (1,000 lux) before bedtime for an additional 5 days. We performed polysomnography (PSG) on the final night of each light exposure period (on nights 2 and night 7) and performed NIRS, which measures the concentrations of oxygenated and deoxygenated hemoglobin (OxyHb and DeoxyHb, respectively), coupled with a Go/NoGo task the following morning (between 09:30 h and 11:30 h). The participants also completed frontal lobe function tests the following morning. Results: NIRS showed decreased hemodynamic activity (lower OxyHb and a tendency toward higher DeoxyHb concentration) in the right frontal lobe during the NoGo block after 1000-lux light exposure compared with that during the NoGo block after 150-lux light exposure. The commission error rate (ER) during the Go/NoGo task was higher after 1000-lux light exposure than that during the Go/NoGo task after 150-lux light exposure (1.24 ± 1.09 vs. 0.6 ± 0.69, P = 0.002), suggesting a reduced inhibitory response. Conclusion: This study shows that exposure to bright light before bedtime for 5 days impairs right frontal lobe activation and response inhibition the following morning.

Original language	English
Pages (from-to)	1035-1044
Number of pages	10
Journal	Chronobiology International
Volume	35
Issue number	8
DOIs	https://doi.org/10.1080/07420528.2018.1452030
Publication status	Published - 2018 Aug 3

Bibliographical note

Funding Information:
This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIP) (No. 2014R1A2A2A04003858).

Publisher Copyright:
© 2018, © 2018 Taylor & Francis Group, LLC.

Keywords

Artificial light
NIRS
frontal lobe function
response inhibition

ASJC Scopus subject areas

Physiology
Physiology (medical)

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10.1080/07420528.2018.1452030

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Byun, J. I., Lee, B. U., Koo, Y. S., Sunwoo, J. S., Lim, J. A., Moon, J., Lee, S. T., Jung, K. H., Chu, K., Kim, M., Lim, J. M., Lee, H. J., Lee, E., Lee, S. K., & Jung, K. Y. (2018). Bright light exposure before bedtime impairs response inhibition the following morning: a non-randomized crossover study. Chronobiology International, 35(8), 1035-1044. https://doi.org/10.1080/07420528.2018.1452030

Byun, JI, Lee, BU, Koo, YS, Sunwoo, JS, Lim, JA, Moon, J, Lee, ST, Jung, KH, Chu, K, Kim, M, Lim, JM, Lee, HJ, Lee, E, Lee, SK & Jung, KY 2018, 'Bright light exposure before bedtime impairs response inhibition the following morning: a non-randomized crossover study', Chronobiology International, vol. 35, no. 8, pp. 1035-1044. https://doi.org/10.1080/07420528.2018.1452030

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title = "Bright light exposure before bedtime impairs response inhibition the following morning: a non-randomized crossover study",

abstract = "Introduction: Bright light exposure in the late evening can affect cognitive function the following morning either by changing the biological clock and/or disturbing sleep, but the evidence for this effect is scarce, and the underlying mechanism remains unknown. In this study, we first aimed to evaluate the effect of bright light exposure before bedtime on frontal lobe activity the following morning using near-infrared spectroscopy (NIRS) during a Go/NoGo task. Second, we aimed to evaluate the effects of bright light exposure before bedtime on polysomnographic measures and on a frontal lobe function test the following morning. Methods: Twenty healthy, young males (mean age, 25.5 years) were recruited between September 2013 and August 2014. They were first exposed to control light (150 lux) before bedtime (from 20:00 h to 24:00 h) for 2 days and then to bright light (1,000 lux) before bedtime for an additional 5 days. We performed polysomnography (PSG) on the final night of each light exposure period (on nights 2 and night 7) and performed NIRS, which measures the concentrations of oxygenated and deoxygenated hemoglobin (OxyHb and DeoxyHb, respectively), coupled with a Go/NoGo task the following morning (between 09:30 h and 11:30 h). The participants also completed frontal lobe function tests the following morning. Results: NIRS showed decreased hemodynamic activity (lower OxyHb and a tendency toward higher DeoxyHb concentration) in the right frontal lobe during the NoGo block after 1000-lux light exposure compared with that during the NoGo block after 150-lux light exposure. The commission error rate (ER) during the Go/NoGo task was higher after 1000-lux light exposure than that during the Go/NoGo task after 150-lux light exposure (1.24 ± 1.09 vs. 0.6 ± 0.69, P = 0.002), suggesting a reduced inhibitory response. Conclusion: This study shows that exposure to bright light before bedtime for 5 days impairs right frontal lobe activation and response inhibition the following morning.",

keywords = "Artificial light, NIRS, frontal lobe function, response inhibition",

author = "Byun, {Jung Ick} and Lee, {Byeong Uk} and Koo, {Yong Seo} and Sunwoo, {Jun Sang} and Lim, {Jung Ah} and Jangsup Moon and Lee, {Soon Tae} and Jung, {Keun Hwa} and Kon Chu and Manho Kim and Lim, {Jong Min} and Lee, {Heon Jeong} and Eunil Lee and Lee, {Sang Kun} and Jung, {Ki Young}",

note = "Funding Information: This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIP) (No. 2014R1A2A2A04003858). Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 Taylor & Francis Group, LLC.",

year = "2018",

month = aug,

day = "3",

doi = "10.1080/07420528.2018.1452030",

language = "English",

volume = "35",

pages = "1035--1044",

journal = "Chronobiology International",

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T1 - Bright light exposure before bedtime impairs response inhibition the following morning

T2 - a non-randomized crossover study

AU - Byun, Jung Ick

AU - Lee, Byeong Uk

AU - Koo, Yong Seo

AU - Sunwoo, Jun Sang

AU - Lim, Jung Ah

AU - Moon, Jangsup

AU - Lee, Soon Tae

AU - Jung, Keun Hwa

AU - Chu, Kon

AU - Kim, Manho

AU - Lim, Jong Min

AU - Lee, Heon Jeong

AU - Lee, Eunil

AU - Lee, Sang Kun

AU - Jung, Ki Young

N1 - Funding Information: This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIP) (No. 2014R1A2A2A04003858). Publisher Copyright: © 2018, © 2018 Taylor & Francis Group, LLC.

PY - 2018/8/3

Y1 - 2018/8/3

N2 - Introduction: Bright light exposure in the late evening can affect cognitive function the following morning either by changing the biological clock and/or disturbing sleep, but the evidence for this effect is scarce, and the underlying mechanism remains unknown. In this study, we first aimed to evaluate the effect of bright light exposure before bedtime on frontal lobe activity the following morning using near-infrared spectroscopy (NIRS) during a Go/NoGo task. Second, we aimed to evaluate the effects of bright light exposure before bedtime on polysomnographic measures and on a frontal lobe function test the following morning. Methods: Twenty healthy, young males (mean age, 25.5 years) were recruited between September 2013 and August 2014. They were first exposed to control light (150 lux) before bedtime (from 20:00 h to 24:00 h) for 2 days and then to bright light (1,000 lux) before bedtime for an additional 5 days. We performed polysomnography (PSG) on the final night of each light exposure period (on nights 2 and night 7) and performed NIRS, which measures the concentrations of oxygenated and deoxygenated hemoglobin (OxyHb and DeoxyHb, respectively), coupled with a Go/NoGo task the following morning (between 09:30 h and 11:30 h). The participants also completed frontal lobe function tests the following morning. Results: NIRS showed decreased hemodynamic activity (lower OxyHb and a tendency toward higher DeoxyHb concentration) in the right frontal lobe during the NoGo block after 1000-lux light exposure compared with that during the NoGo block after 150-lux light exposure. The commission error rate (ER) during the Go/NoGo task was higher after 1000-lux light exposure than that during the Go/NoGo task after 150-lux light exposure (1.24 ± 1.09 vs. 0.6 ± 0.69, P = 0.002), suggesting a reduced inhibitory response. Conclusion: This study shows that exposure to bright light before bedtime for 5 days impairs right frontal lobe activation and response inhibition the following morning.

AB - Introduction: Bright light exposure in the late evening can affect cognitive function the following morning either by changing the biological clock and/or disturbing sleep, but the evidence for this effect is scarce, and the underlying mechanism remains unknown. In this study, we first aimed to evaluate the effect of bright light exposure before bedtime on frontal lobe activity the following morning using near-infrared spectroscopy (NIRS) during a Go/NoGo task. Second, we aimed to evaluate the effects of bright light exposure before bedtime on polysomnographic measures and on a frontal lobe function test the following morning. Methods: Twenty healthy, young males (mean age, 25.5 years) were recruited between September 2013 and August 2014. They were first exposed to control light (150 lux) before bedtime (from 20:00 h to 24:00 h) for 2 days and then to bright light (1,000 lux) before bedtime for an additional 5 days. We performed polysomnography (PSG) on the final night of each light exposure period (on nights 2 and night 7) and performed NIRS, which measures the concentrations of oxygenated and deoxygenated hemoglobin (OxyHb and DeoxyHb, respectively), coupled with a Go/NoGo task the following morning (between 09:30 h and 11:30 h). The participants also completed frontal lobe function tests the following morning. Results: NIRS showed decreased hemodynamic activity (lower OxyHb and a tendency toward higher DeoxyHb concentration) in the right frontal lobe during the NoGo block after 1000-lux light exposure compared with that during the NoGo block after 150-lux light exposure. The commission error rate (ER) during the Go/NoGo task was higher after 1000-lux light exposure than that during the Go/NoGo task after 150-lux light exposure (1.24 ± 1.09 vs. 0.6 ± 0.69, P = 0.002), suggesting a reduced inhibitory response. Conclusion: This study shows that exposure to bright light before bedtime for 5 days impairs right frontal lobe activation and response inhibition the following morning.

KW - Artificial light

KW - NIRS

KW - frontal lobe function

KW - response inhibition

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Bright light exposure before bedtime impairs response inhibition the following morning: a non-randomized crossover study

Abstract

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