BRM270, a Compound from Natural Plant Extracts, Inhibits Glioblastoma Stem Cell Properties and Glioblastoma Recurrence

Hee Young Jeon; Cheol Gyu Park; Seok Won Ham; Sang Hun Choi; Seon Yong Lee; Jung Yun Kim; Sunyoung Seo; Xiong Jin; Jun Kyum Kim; Kiyoung Eun; Eun Jung Kim; Hyunggee Kim

doi:10.1089/jmf.2017.3929

BRM270, a Compound from Natural Plant Extracts, Inhibits Glioblastoma Stem Cell Properties and Glioblastoma Recurrence

Hee Young Jeon, Cheol Gyu Park, Seok Won Ham, Sang Hun Choi, Seon Yong Lee, Jung Yun Kim, Sunyoung Seo, Xiong Jin, Jun Kyum Kim, Kiyoung Eun, Eun Jung Kim, Hyunggee Kim

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Glioblastoma multiforme (GBM) is one of the most aggressive and lethal human brain tumors, and the median survival of patients with GBM is only 14 months. Glioblastoma stem cells (GSCs) are regarded as a main cause of GBM recurrence, because of their self-renewal and drug resistance properties. Therefore, targeting GSCs is an important therapeutic strategy for GBM. In this study, we show the effects of BRM270, a compound from natural plant extracts, on GSCs in vitro and GBM recurrence in vivo. BRM270 induced apoptotic cell death and inhibited cell growth and "stemness" both in vitro and in vivo. Combining BRM270 treatment with concurrent chemoradiotherapy (CCRT) dramatically increased mice survival and tumor growth inhibition. Taken together, our results suggested that BRM270 synergizes with CCRT as a therapeutic agent to target GSCs.

Original language	English
Pages (from-to)	838-845
Number of pages	8
Journal	Journal of Medicinal Food
Volume	20
Issue number	9
DOIs	https://doi.org/10.1089/jmf.2017.3929
Publication status	Published - 2017 Sept

Bibliographical note

Publisher Copyright:
© Copyright 2017, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2017.

Keywords

BRM270
concurrent chemoradiotherapy
glioblastoma multiforme
glioblastoma stem cells
natural plant extract

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

Access to Document

10.1089/jmf.2017.3929

Cite this

@article{bc0fc5952a7a4306857772b441a79b22,

title = "BRM270, a Compound from Natural Plant Extracts, Inhibits Glioblastoma Stem Cell Properties and Glioblastoma Recurrence",

abstract = "Glioblastoma multiforme (GBM) is one of the most aggressive and lethal human brain tumors, and the median survival of patients with GBM is only 14 months. Glioblastoma stem cells (GSCs) are regarded as a main cause of GBM recurrence, because of their self-renewal and drug resistance properties. Therefore, targeting GSCs is an important therapeutic strategy for GBM. In this study, we show the effects of BRM270, a compound from natural plant extracts, on GSCs in vitro and GBM recurrence in vivo. BRM270 induced apoptotic cell death and inhibited cell growth and {"}stemness{"} both in vitro and in vivo. Combining BRM270 treatment with concurrent chemoradiotherapy (CCRT) dramatically increased mice survival and tumor growth inhibition. Taken together, our results suggested that BRM270 synergizes with CCRT as a therapeutic agent to target GSCs.",

keywords = "BRM270, concurrent chemoradiotherapy, glioblastoma multiforme, glioblastoma stem cells, natural plant extract",

author = "Jeon, {Hee Young} and Park, {Cheol Gyu} and Ham, {Seok Won} and Choi, {Sang Hun} and Lee, {Seon Yong} and Kim, {Jung Yun} and Sunyoung Seo and Xiong Jin and Kim, {Jun Kyum} and Kiyoung Eun and Kim, {Eun Jung} and Hyunggee Kim",

year = "2017",

month = sep,

doi = "10.1089/jmf.2017.3929",

language = "English",

volume = "20",

pages = "838--845",

journal = "Journal of Medicinal Food",

issn = "1096-620X",

publisher = "Mary Ann Liebert Inc.",

number = "9",

}

TY - JOUR

T1 - BRM270, a Compound from Natural Plant Extracts, Inhibits Glioblastoma Stem Cell Properties and Glioblastoma Recurrence

AU - Jeon, Hee Young

AU - Park, Cheol Gyu

AU - Ham, Seok Won

AU - Choi, Sang Hun

AU - Lee, Seon Yong

AU - Kim, Jung Yun

AU - Seo, Sunyoung

AU - Jin, Xiong

AU - Kim, Jun Kyum

AU - Eun, Kiyoung

AU - Kim, Eun Jung

AU - Kim, Hyunggee

PY - 2017/9

Y1 - 2017/9

N2 - Glioblastoma multiforme (GBM) is one of the most aggressive and lethal human brain tumors, and the median survival of patients with GBM is only 14 months. Glioblastoma stem cells (GSCs) are regarded as a main cause of GBM recurrence, because of their self-renewal and drug resistance properties. Therefore, targeting GSCs is an important therapeutic strategy for GBM. In this study, we show the effects of BRM270, a compound from natural plant extracts, on GSCs in vitro and GBM recurrence in vivo. BRM270 induced apoptotic cell death and inhibited cell growth and "stemness" both in vitro and in vivo. Combining BRM270 treatment with concurrent chemoradiotherapy (CCRT) dramatically increased mice survival and tumor growth inhibition. Taken together, our results suggested that BRM270 synergizes with CCRT as a therapeutic agent to target GSCs.

AB - Glioblastoma multiforme (GBM) is one of the most aggressive and lethal human brain tumors, and the median survival of patients with GBM is only 14 months. Glioblastoma stem cells (GSCs) are regarded as a main cause of GBM recurrence, because of their self-renewal and drug resistance properties. Therefore, targeting GSCs is an important therapeutic strategy for GBM. In this study, we show the effects of BRM270, a compound from natural plant extracts, on GSCs in vitro and GBM recurrence in vivo. BRM270 induced apoptotic cell death and inhibited cell growth and "stemness" both in vitro and in vivo. Combining BRM270 treatment with concurrent chemoradiotherapy (CCRT) dramatically increased mice survival and tumor growth inhibition. Taken together, our results suggested that BRM270 synergizes with CCRT as a therapeutic agent to target GSCs.

KW - BRM270

KW - concurrent chemoradiotherapy

KW - glioblastoma multiforme

KW - glioblastoma stem cells

KW - natural plant extract

UR - http://www.scopus.com/inward/record.url?scp=85029233407&partnerID=8YFLogxK

U2 - 10.1089/jmf.2017.3929

DO - 10.1089/jmf.2017.3929

M3 - Article

C2 - 28792781

AN - SCOPUS:85029233407

SN - 1096-620X

VL - 20

SP - 838

EP - 845

JO - Journal of Medicinal Food

JF - Journal of Medicinal Food

IS - 9

ER -

BRM270, a Compound from Natural Plant Extracts, Inhibits Glioblastoma Stem Cell Properties and Glioblastoma Recurrence

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this