Bronchoalveolar cellularity and interleukin-8 levels in measles bronchiolitis obliterans

Young Yull Koh, Da Eun Jung, Ji Yeon Koh, Jung Yeon Kim, Young Yoo, Chang Keun Kim

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    47 Citations (Scopus)

    Abstract

    Background: Measles virus infection may progress to a chronic obstructive process including bronchiolitis obliterans (BO). This study investigates pulmonary cellular profiles and interleukin (IL)-8 levels in patients with BO following the measles. Methods: BAL fluid was obtained from 12 children with BO who had a history of measles pneumonia during an outbreak in 2000 and 2001. BAL cell counts and differentials were compared to control patients as well as BAL IL-8 levels, which were measured by enzyme-linked immunosorbent assay. Immunohistochemical staining of BAL cells and three open-lung biopsy specimens were also analyzed for T-cell surface markers CD3, CD4, and CD8. Results: BAL cellular profiles were characterized by a significantly increased percentage of neutrophils in the measles BO group (median, 16.0%) compared to the control group (2.3%) [p < 0.01]. BAL IL-8 levels were also markedly increased in the measles BO group (mean ± SD, 418.6 ± 286.0 pg/mL) compared to the control group (92.8 ± 126.7 pg/mL) [p < 0.01]. BAL IL-8 levels correlated significantly with neutrophil percentages in both the measles BO group (r = 0.86, p = 0.000) and the control group (r = 0.79, p = 0.007). The lymphocyte subsets were characterized by a significantly increased number of CD8+ cells, resulting in a decreased CD4/CD8 ratio in the BAL and the biopsy specimens. Conclusion: These results suggest that pulmonary neutrophils and IL-8, along with CD8+ T lymphocytes may play an important role in the pathogenesis of BO after measles virus infection.

    Original languageEnglish
    Pages (from-to)1454-1460
    Number of pages7
    JournalChest
    Volume131
    Issue number5
    DOIs
    Publication statusPublished - 2007 May

    Bibliographical note

    Funding Information:
    This work was supported in part by the 2005 Inje University research grant. This study was supported in part by BK 21 Project for Medicine, Dentistry, and Pharmacy, Seoul National University.

    Keywords

    • Bronchiolitis obliterans
    • CD8
    • Interleukin-8
    • Measles
    • Neutrophils

    ASJC Scopus subject areas

    • Pulmonary and Respiratory Medicine
    • Critical Care and Intensive Care Medicine
    • Cardiology and Cardiovascular Medicine

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