Brown rice (Oryza sativa L. cv. Hiami) extract promotes cellular growth by upregulation of GH and IGF-1 expression and secretion

Hyun seok Oh; Se Kwan Oh; Jum Seek Lee; June Seek Choi; Sung Joon Lee

doi:10.1007/s10068-016-0047-1

Brown rice (Oryza sativa L. cv. Hiami) extract promotes cellular growth by upregulation of GH and IGF-1 expression and secretion

Hyun seok Oh, Se Kwan Oh, Jum Seek Lee, June Seek Choi, Sung Joon Lee

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of the ethanolic extract of brown rice (BRE, Oryza sativa L. cv. Hiami) on cellular growth were investigated. Gene expression analysis by qPCR showed that the expression of the mRNA expressions of growth hormone (GH) and insulin-like growth factor (IGF)-1 genes was significantly induced in cells stimulated with BRE compared with controls, and the effects were dose dependent. In addition, the hormone secretion of GH and IGF-1 was significantly induced in GH3 and HepG2 cells stimulated with BRE in line with the qPCR results. Collectively, these results suggest that BRE induces the expression and secretion of GH and IGF-1 in vitro; therefore, application may promote cellular growth.

Original language	English
Pages (from-to)	335-339
Number of pages	5
Journal	Food Science and Biotechnology
Volume	25
Issue number	1
DOIs	https://doi.org/10.1007/s10068-016-0047-1
Publication status	Published - 2016 Feb 1

Bibliographical note

Publisher Copyright:
© 2016, The Korean Society of Food Science and Technology and Springer Science+Business Media Dordrecht.

Keywords

IGF-1
IGFBP-1
brown rice
growth
growth hormone

ASJC Scopus subject areas

Biotechnology
Food Science
Applied Microbiology and Biotechnology

Access to Document

10.1007/s10068-016-0047-1

Cite this

@article{089aa2c9865e4be2834f53d7fea25ea9,

title = "Brown rice (Oryza sativa L. cv. Hiami) extract promotes cellular growth by upregulation of GH and IGF-1 expression and secretion",

abstract = "The effects of the ethanolic extract of brown rice (BRE, Oryza sativa L. cv. Hiami) on cellular growth were investigated. Gene expression analysis by qPCR showed that the expression of the mRNA expressions of growth hormone (GH) and insulin-like growth factor (IGF)-1 genes was significantly induced in cells stimulated with BRE compared with controls, and the effects were dose dependent. In addition, the hormone secretion of GH and IGF-1 was significantly induced in GH3 and HepG2 cells stimulated with BRE in line with the qPCR results. Collectively, these results suggest that BRE induces the expression and secretion of GH and IGF-1 in vitro; therefore, application may promote cellular growth.",

keywords = "IGF-1, IGFBP-1, brown rice, growth, growth hormone",

author = "Oh, {Hyun seok} and Oh, {Se Kwan} and Lee, {Jum Seek} and Choi, {June Seek} and Lee, {Sung Joon}",

note = "Publisher Copyright: {\textcopyright} 2016, The Korean Society of Food Science and Technology and Springer Science+Business Media Dordrecht.",

year = "2016",

month = feb,

day = "1",

doi = "10.1007/s10068-016-0047-1",

language = "English",

volume = "25",

pages = "335--339",

journal = "Food Science and Biotechnology",

issn = "1226-7708",

publisher = "Springer Netherlands",

number = "1",

}

TY - JOUR

T1 - Brown rice (Oryza sativa L. cv. Hiami) extract promotes cellular growth by upregulation of GH and IGF-1 expression and secretion

AU - Oh, Hyun seok

AU - Oh, Se Kwan

AU - Lee, Jum Seek

AU - Choi, June Seek

AU - Lee, Sung Joon

PY - 2016/2/1

Y1 - 2016/2/1

N2 - The effects of the ethanolic extract of brown rice (BRE, Oryza sativa L. cv. Hiami) on cellular growth were investigated. Gene expression analysis by qPCR showed that the expression of the mRNA expressions of growth hormone (GH) and insulin-like growth factor (IGF)-1 genes was significantly induced in cells stimulated with BRE compared with controls, and the effects were dose dependent. In addition, the hormone secretion of GH and IGF-1 was significantly induced in GH3 and HepG2 cells stimulated with BRE in line with the qPCR results. Collectively, these results suggest that BRE induces the expression and secretion of GH and IGF-1 in vitro; therefore, application may promote cellular growth.

AB - The effects of the ethanolic extract of brown rice (BRE, Oryza sativa L. cv. Hiami) on cellular growth were investigated. Gene expression analysis by qPCR showed that the expression of the mRNA expressions of growth hormone (GH) and insulin-like growth factor (IGF)-1 genes was significantly induced in cells stimulated with BRE compared with controls, and the effects were dose dependent. In addition, the hormone secretion of GH and IGF-1 was significantly induced in GH3 and HepG2 cells stimulated with BRE in line with the qPCR results. Collectively, these results suggest that BRE induces the expression and secretion of GH and IGF-1 in vitro; therefore, application may promote cellular growth.

KW - IGF-1

KW - IGFBP-1

KW - brown rice

KW - growth

KW - growth hormone

UR - http://www.scopus.com/inward/record.url?scp=84958242491&partnerID=8YFLogxK

U2 - 10.1007/s10068-016-0047-1

DO - 10.1007/s10068-016-0047-1

M3 - Article

C2 - 30263275

AN - SCOPUS:84958242491

SN - 1226-7708

VL - 25

SP - 335

EP - 339

JO - Food Science and Biotechnology

JF - Food Science and Biotechnology

IS - 1

ER -

Brown rice (Oryza sativa L. cv. Hiami) extract promotes cellular growth by upregulation of GH and IGF-1 expression and secretion

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this