C-C Bond Cleavage-Induced C- to N-Acyl Transfer for Synthesis of Amides

Su Eun Lee; Youngsoo Kim; Yong Ho Lee; Hee Nam Lim

doi:10.1021/acs.orglett.4c01154

C-C Bond Cleavage-Induced C- to N-Acyl Transfer for Synthesis of Amides

Su Eun Lee, Youngsoo Kim, Yong Ho Lee, Hee Nam Lim

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A new approach for the preparation of amides was developed using C-C bond cleavage that initiates C- to N-acyl transfer, employing activated ketones as acylation reagents and amine nucleophiles. The reaction was operational under the coupling reagent system that is commonly utilized for peptide bond formations. The method enables practical preparation of amides using linear and cyclic ketone substrates under mild conditions.

Original language	English
Pages (from-to)	3646-3651
Number of pages	6
Journal	Organic Letters
Volume	26
Issue number	17
DOIs	https://doi.org/10.1021/acs.orglett.4c01154
Publication status	Published - 2024 May 3

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Publisher Copyright:
© 2024 American Chemical Society.

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.4c01154

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abstract = "A new approach for the preparation of amides was developed using C-C bond cleavage that initiates C- to N-acyl transfer, employing activated ketones as acylation reagents and amine nucleophiles. The reaction was operational under the coupling reagent system that is commonly utilized for peptide bond formations. The method enables practical preparation of amides using linear and cyclic ketone substrates under mild conditions.",

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AU - Kim, Youngsoo

AU - Lee, Yong Ho

AU - Lim, Hee Nam

PY - 2024/5/3

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AB - A new approach for the preparation of amides was developed using C-C bond cleavage that initiates C- to N-acyl transfer, employing activated ketones as acylation reagents and amine nucleophiles. The reaction was operational under the coupling reagent system that is commonly utilized for peptide bond formations. The method enables practical preparation of amides using linear and cyclic ketone substrates under mild conditions.

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C-C Bond Cleavage-Induced C- to N-Acyl Transfer for Synthesis of Amides

Abstract

Bibliographical note

ASJC Scopus subject areas

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