Caloric restriction improves efficiency and capacity of the mitochondrial electron transport chain in Saccharomyces cerevisiae

Joon Seok Choi; Kyung Mi Choi; Cheol Koo Lee

doi:10.1016/j.bbrc.2011.05.008

Caloric restriction improves efficiency and capacity of the mitochondrial electron transport chain in Saccharomyces cerevisiae

Joon Seok Choi, Kyung Mi Choi, Cheol Koo Lee

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Caloric restriction (CR) is known to extend lifespan in a variety of species; however, the mechanism remains unclear. In this study, we found that CR potentiated the mitochondrial electron transport chain (ETC) at both the transcriptional and translational levels. Indeed, mitochondrial membrane potential (MMP) was increased by CR, and, regardless of ages, overall reactive oxygen species (ROS) generation was decreased by CR. With these changes, overall growth rate of cells was maintained under various CR conditions, just like cells under a non-restricted condition. All of these data support increased efficiency and capacity of the ETC by CR, and this change might lead to extension of lifespan.

Original language	English
Pages (from-to)	308-314
Number of pages	7
Journal	Biochemical and biophysical research communications
Volume	409
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2011.05.008
Publication status	Published - 2011 Jun 3

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MEST) (Nos. 2008-0061063 and 2009-0084110 ) to C.K.L., as well as by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MEST) (No. 351-2009-1-C00063 ) to J.S.C.

Keywords

Caloric restriction
Growth rate
Lifespan extension
Mitochondrial electron transport chain
Mitochondrial membrane potential
Reactive oxygen species

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2011.05.008

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title = "Caloric restriction improves efficiency and capacity of the mitochondrial electron transport chain in Saccharomyces cerevisiae",

abstract = "Caloric restriction (CR) is known to extend lifespan in a variety of species; however, the mechanism remains unclear. In this study, we found that CR potentiated the mitochondrial electron transport chain (ETC) at both the transcriptional and translational levels. Indeed, mitochondrial membrane potential (MMP) was increased by CR, and, regardless of ages, overall reactive oxygen species (ROS) generation was decreased by CR. With these changes, overall growth rate of cells was maintained under various CR conditions, just like cells under a non-restricted condition. All of these data support increased efficiency and capacity of the ETC by CR, and this change might lead to extension of lifespan.",

keywords = "Caloric restriction, Growth rate, Lifespan extension, Mitochondrial electron transport chain, Mitochondrial membrane potential, Reactive oxygen species",

author = "Choi, {Joon Seok} and Choi, {Kyung Mi} and Lee, {Cheol Koo}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MEST) (Nos. 2008-0061063 and 2009-0084110 ) to C.K.L., as well as by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MEST) (No. 351-2009-1-C00063 ) to J.S.C.",

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doi = "10.1016/j.bbrc.2011.05.008",

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AU - Choi, Joon Seok

AU - Choi, Kyung Mi

AU - Lee, Cheol Koo

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MEST) (Nos. 2008-0061063 and 2009-0084110 ) to C.K.L., as well as by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MEST) (No. 351-2009-1-C00063 ) to J.S.C.

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N2 - Caloric restriction (CR) is known to extend lifespan in a variety of species; however, the mechanism remains unclear. In this study, we found that CR potentiated the mitochondrial electron transport chain (ETC) at both the transcriptional and translational levels. Indeed, mitochondrial membrane potential (MMP) was increased by CR, and, regardless of ages, overall reactive oxygen species (ROS) generation was decreased by CR. With these changes, overall growth rate of cells was maintained under various CR conditions, just like cells under a non-restricted condition. All of these data support increased efficiency and capacity of the ETC by CR, and this change might lead to extension of lifespan.

AB - Caloric restriction (CR) is known to extend lifespan in a variety of species; however, the mechanism remains unclear. In this study, we found that CR potentiated the mitochondrial electron transport chain (ETC) at both the transcriptional and translational levels. Indeed, mitochondrial membrane potential (MMP) was increased by CR, and, regardless of ages, overall reactive oxygen species (ROS) generation was decreased by CR. With these changes, overall growth rate of cells was maintained under various CR conditions, just like cells under a non-restricted condition. All of these data support increased efficiency and capacity of the ETC by CR, and this change might lead to extension of lifespan.

KW - Caloric restriction

KW - Growth rate

KW - Lifespan extension

KW - Mitochondrial electron transport chain

KW - Mitochondrial membrane potential

KW - Reactive oxygen species

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ER -

Caloric restriction improves efficiency and capacity of the mitochondrial electron transport chain in Saccharomyces cerevisiae

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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