Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis

Seung Bae Rho, Hyun Jung Byun, Sang Yoon Park, Taehoon Chun

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)

    Abstract

    Since calpain 6 is overexpressed in uterine cervical cancer tissue compared to normal tissue, we sought to define the role of calpain 6 during tumorigenesis. We overexpressed calpain 6 or inhibited calpain 6 in human cervical cancer cells (HeLa cells) and human umbilical vein endothelial cells (HUVECs), and measured cisplatin-mediated apoptosis and VEGF-mediated angiogenesis. The results indicated that calpain 6 supported tumorigenesis by inhibiting apoptosis and facilitating angiogenesis. To our knowledge, this result is the first evidence implicating calpain 6 in tumorigenesis, and it reveals calpain 6 as a novel therapeutic target for certain types of cancers.

    Original languageEnglish
    Pages (from-to)306-313
    Number of pages8
    JournalCancer letters
    Volume271
    Issue number2
    DOIs
    Publication statusPublished - 2008 Nov 28

    Keywords

    • Angiogenesis
    • Apoptosis
    • Calpain 6
    • Endothelial cell
    • Ovarian carcinoma cell

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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