Abstract
Since calpain 6 is overexpressed in uterine cervical cancer tissue compared to normal tissue, we sought to define the role of calpain 6 during tumorigenesis. We overexpressed calpain 6 or inhibited calpain 6 in human cervical cancer cells (HeLa cells) and human umbilical vein endothelial cells (HUVECs), and measured cisplatin-mediated apoptosis and VEGF-mediated angiogenesis. The results indicated that calpain 6 supported tumorigenesis by inhibiting apoptosis and facilitating angiogenesis. To our knowledge, this result is the first evidence implicating calpain 6 in tumorigenesis, and it reveals calpain 6 as a novel therapeutic target for certain types of cancers.
Original language | English |
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Pages (from-to) | 306-313 |
Number of pages | 8 |
Journal | Cancer letters |
Volume | 271 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2008 Nov 28 |
Keywords
- Angiogenesis
- Apoptosis
- Calpain 6
- Endothelial cell
- Ovarian carcinoma cell
ASJC Scopus subject areas
- Oncology
- Cancer Research