Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis

Seung Bae Rho; Hyun Jung Byun; Sang Yoon Park; Taehoon Chun

doi:10.1016/j.canlet.2008.06.020

Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis

Seung Bae Rho, Hyun Jung Byun, Sang Yoon Park, Taehoon Chun

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Since calpain 6 is overexpressed in uterine cervical cancer tissue compared to normal tissue, we sought to define the role of calpain 6 during tumorigenesis. We overexpressed calpain 6 or inhibited calpain 6 in human cervical cancer cells (HeLa cells) and human umbilical vein endothelial cells (HUVECs), and measured cisplatin-mediated apoptosis and VEGF-mediated angiogenesis. The results indicated that calpain 6 supported tumorigenesis by inhibiting apoptosis and facilitating angiogenesis. To our knowledge, this result is the first evidence implicating calpain 6 in tumorigenesis, and it reveals calpain 6 as a novel therapeutic target for certain types of cancers.

Original language	English
Pages (from-to)	306-313
Number of pages	8
Journal	Cancer letters
Volume	271
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2008.06.020
Publication status	Published - 2008 Nov 28

Keywords

Angiogenesis
Apoptosis
Calpain 6
Endothelial cell
Ovarian carcinoma cell

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2008.06.020

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title = "Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis",

abstract = "Since calpain 6 is overexpressed in uterine cervical cancer tissue compared to normal tissue, we sought to define the role of calpain 6 during tumorigenesis. We overexpressed calpain 6 or inhibited calpain 6 in human cervical cancer cells (HeLa cells) and human umbilical vein endothelial cells (HUVECs), and measured cisplatin-mediated apoptosis and VEGF-mediated angiogenesis. The results indicated that calpain 6 supported tumorigenesis by inhibiting apoptosis and facilitating angiogenesis. To our knowledge, this result is the first evidence implicating calpain 6 in tumorigenesis, and it reveals calpain 6 as a novel therapeutic target for certain types of cancers.",

keywords = "Angiogenesis, Apoptosis, Calpain 6, Endothelial cell, Ovarian carcinoma cell",

author = "Rho, {Seung Bae} and Byun, {Hyun Jung} and Park, {Sang Yoon} and Taehoon Chun",

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doi = "10.1016/j.canlet.2008.06.020",

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volume = "271",

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journal = "Cancer Letters",

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T1 - Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis

AU - Rho, Seung Bae

AU - Byun, Hyun Jung

AU - Park, Sang Yoon

AU - Chun, Taehoon

PY - 2008/11/28

Y1 - 2008/11/28

N2 - Since calpain 6 is overexpressed in uterine cervical cancer tissue compared to normal tissue, we sought to define the role of calpain 6 during tumorigenesis. We overexpressed calpain 6 or inhibited calpain 6 in human cervical cancer cells (HeLa cells) and human umbilical vein endothelial cells (HUVECs), and measured cisplatin-mediated apoptosis and VEGF-mediated angiogenesis. The results indicated that calpain 6 supported tumorigenesis by inhibiting apoptosis and facilitating angiogenesis. To our knowledge, this result is the first evidence implicating calpain 6 in tumorigenesis, and it reveals calpain 6 as a novel therapeutic target for certain types of cancers.

AB - Since calpain 6 is overexpressed in uterine cervical cancer tissue compared to normal tissue, we sought to define the role of calpain 6 during tumorigenesis. We overexpressed calpain 6 or inhibited calpain 6 in human cervical cancer cells (HeLa cells) and human umbilical vein endothelial cells (HUVECs), and measured cisplatin-mediated apoptosis and VEGF-mediated angiogenesis. The results indicated that calpain 6 supported tumorigenesis by inhibiting apoptosis and facilitating angiogenesis. To our knowledge, this result is the first evidence implicating calpain 6 in tumorigenesis, and it reveals calpain 6 as a novel therapeutic target for certain types of cancers.

KW - Angiogenesis

KW - Apoptosis

KW - Calpain 6

KW - Endothelial cell

KW - Ovarian carcinoma cell

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DO - 10.1016/j.canlet.2008.06.020

M3 - Article

C2 - 18657900

AN - SCOPUS:53449095522

SN - 0304-3835

VL - 271

SP - 306

EP - 313

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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