Camptothecin delivery into hepatoma cell line by galactose-appended fluorescent drug delivery system

Sun Dongbang, Hyun Mi Jeon, Min Hee Lee, Weon Sup Shin, Joon Kook Kwon, Chulhun Kang, Jong Seung Kim

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    A galactose-appended camptothecin prodrug was newly synthesized. The prodrug preferentially entered a hepatoma cell line due to the galactose unit and the drug release triggered by disulfide-bond cleavage via reaction with glutathione was visualized on the basis of fluorescence changes of the naphthalimide moiety. The prodrug entered the cells via receptor-mediated endocytosis and released drug molecules into lysosomes, however, the released drug molecules failed to show significant anticancer activity, probably due to lysosomal hydrolysis of their lactone ring converting them to an inactive carboxylate form.

    Original languageEnglish
    Pages (from-to)18744-18748
    Number of pages5
    JournalRSC Advances
    Volume4
    Issue number36
    DOIs
    Publication statusPublished - 2014

    ASJC Scopus subject areas

    • General Chemistry
    • General Chemical Engineering

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