Cancer Mechanobiology: Microenvironmental Sensing and Metastasis

Geonhui Lee; Seong Beom Han; Jung Hwan Lee; Hae Won Kim; Dong Hwee Kim

doi:10.1021/acsbiomaterials.8b01230

Cancer Mechanobiology: Microenvironmental Sensing and Metastasis

Geonhui Lee, Seong Beom Han, Jung Hwan Lee, Hae Won Kim, Dong Hwee Kim

KU-KIST Graduate School of Converging Science and Technology

Research output: Contribution to journal › Review article › peer-review

31 Citations (Scopus)

Abstract

The cellular microenvironment plays an important role in regulating cancer progress. Cancer can physically and chemically remodel its surrounding extracellular matrix (ECM). Critical cellular behaviors such as recognition of matrix geometry and rigidity, cell polarization and motility, cytoskeletal reorganization, and proliferation can be changed as a consequence of these ECM alternations. Here, we present an overview of cancer mechanobiology in detail, focusing on cancer microenvironmental sensing of exogenous cues and quantification of cancer-substrate interactions. In addition, mechanics of metastasis classified with tumor progression will be discussed. The mechanism underlying cancer mechanosensation and tumor progression may provide new insights into therapeutic strategies to alleviate cancer malignancy.

Original language	English
Pages (from-to)	3735-3752
Number of pages	18
Journal	ACS Biomaterials Science and Engineering
Volume	5
Issue number	8
DOIs	https://doi.org/10.1021/acsbiomaterials.8b01230
Publication status	Published - 2019 Aug 12

Keywords

mechanosensation
mechanotransduction
metastatic potential
physics of cancer
tumor microenvironment

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acsbiomaterials.8b01230

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@article{44835835200f4f8ebd90545053f37daa,

title = "Cancer Mechanobiology: Microenvironmental Sensing and Metastasis",

abstract = "The cellular microenvironment plays an important role in regulating cancer progress. Cancer can physically and chemically remodel its surrounding extracellular matrix (ECM). Critical cellular behaviors such as recognition of matrix geometry and rigidity, cell polarization and motility, cytoskeletal reorganization, and proliferation can be changed as a consequence of these ECM alternations. Here, we present an overview of cancer mechanobiology in detail, focusing on cancer microenvironmental sensing of exogenous cues and quantification of cancer-substrate interactions. In addition, mechanics of metastasis classified with tumor progression will be discussed. The mechanism underlying cancer mechanosensation and tumor progression may provide new insights into therapeutic strategies to alleviate cancer malignancy.",

keywords = "mechanosensation, mechanotransduction, metastatic potential, physics of cancer, tumor microenvironment",

author = "Geonhui Lee and Han, {Seong Beom} and Lee, {Jung Hwan} and Kim, {Hae Won} and Kim, {Dong Hwee}",

note = "Funding Information: The authors thank Dr. Dong-Hwee Kim{\textquoteright}s Applied Mechanobi-ology Group (AMG) at Korea University and Dr. Hae-Won Kim{\textquoteright}s Institute of Tissue Regeneration Engineering (ITREN) at Dankook University for thoughtful discussion. This work was supported by the KU-KIST Graduate School of Converging Science and Technology Program, Korea University Future Research Grants, and National Research Foundation of Korea (2016R1C1B2015018). Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

month = aug,

day = "12",

doi = "10.1021/acsbiomaterials.8b01230",

language = "English",

volume = "5",

pages = "3735--3752",

journal = "ACS Biomaterials Science and Engineering",

issn = "2373-9878",

publisher = "American Chemical Society",

number = "8",

}

TY - JOUR

T1 - Cancer Mechanobiology

T2 - Microenvironmental Sensing and Metastasis

AU - Lee, Geonhui

AU - Han, Seong Beom

AU - Lee, Jung Hwan

AU - Kim, Hae Won

AU - Kim, Dong Hwee

N1 - Funding Information: The authors thank Dr. Dong-Hwee Kim’s Applied Mechanobi-ology Group (AMG) at Korea University and Dr. Hae-Won Kim’s Institute of Tissue Regeneration Engineering (ITREN) at Dankook University for thoughtful discussion. This work was supported by the KU-KIST Graduate School of Converging Science and Technology Program, Korea University Future Research Grants, and National Research Foundation of Korea (2016R1C1B2015018). Publisher Copyright: © 2019 American Chemical Society.

PY - 2019/8/12

Y1 - 2019/8/12

N2 - The cellular microenvironment plays an important role in regulating cancer progress. Cancer can physically and chemically remodel its surrounding extracellular matrix (ECM). Critical cellular behaviors such as recognition of matrix geometry and rigidity, cell polarization and motility, cytoskeletal reorganization, and proliferation can be changed as a consequence of these ECM alternations. Here, we present an overview of cancer mechanobiology in detail, focusing on cancer microenvironmental sensing of exogenous cues and quantification of cancer-substrate interactions. In addition, mechanics of metastasis classified with tumor progression will be discussed. The mechanism underlying cancer mechanosensation and tumor progression may provide new insights into therapeutic strategies to alleviate cancer malignancy.

AB - The cellular microenvironment plays an important role in regulating cancer progress. Cancer can physically and chemically remodel its surrounding extracellular matrix (ECM). Critical cellular behaviors such as recognition of matrix geometry and rigidity, cell polarization and motility, cytoskeletal reorganization, and proliferation can be changed as a consequence of these ECM alternations. Here, we present an overview of cancer mechanobiology in detail, focusing on cancer microenvironmental sensing of exogenous cues and quantification of cancer-substrate interactions. In addition, mechanics of metastasis classified with tumor progression will be discussed. The mechanism underlying cancer mechanosensation and tumor progression may provide new insights into therapeutic strategies to alleviate cancer malignancy.

KW - mechanosensation

KW - mechanotransduction

KW - metastatic potential

KW - physics of cancer

KW - tumor microenvironment

UR - http://www.scopus.com/inward/record.url?scp=85061253689&partnerID=8YFLogxK

U2 - 10.1021/acsbiomaterials.8b01230

DO - 10.1021/acsbiomaterials.8b01230

M3 - Review article

C2 - 33405888

AN - SCOPUS:85061253689

SN - 2373-9878

VL - 5

SP - 3735

EP - 3752

JO - ACS Biomaterials Science and Engineering

JF - ACS Biomaterials Science and Engineering

IS - 8

ER -

Cancer Mechanobiology: Microenvironmental Sensing and Metastasis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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