TY - JOUR
T1 - Cancer targeting strategies in nanomedicine
T2 - Design and application of chitosan nanoparticles
AU - Jee, Jun Pil
AU - Na, Jin Hee
AU - Lee, Sangmin
AU - Kim, Sun Hwa
AU - Choi, Kuiwon
AU - Yeo, Yoon
AU - Kwon, Ick Chan
N1 - Funding Information:
This work is supported by the GRL Program (2010-0019863) and Global Innovative Research Center program of the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology, by a grant of the Korea Healthcare technology R&D Project of Ministry for Health, Welfare & Family Affairs (A110879) and by the Intramural Research Program of KIST.
PY - 2012/12
Y1 - 2012/12
N2 - Nanomedicine has recently emerged as an efficient way of overcoming various limitations of conventional medicine, such as a lack of selectivity, poor pharmacokinetics and undesirable side effects. Especially, nanoparticles (NPs) technology has attracted more attentions in nanomedicine based approaches for cancer therapy due to unique physicochemical properties. Although NPs have been intensively studied for tumor targeting and showed some promising results, there is still limited understanding about pharmacokinetic (PK) and pharmacodynamic (PD) properties and tumor targeting efficiency of NPs. Thus, advances in understanding of these issues in NPs technology can create more opportunities to translate nanomedicine approaches into improved clinical outcomes. The goal of this review is to understand the key factors that are required for tumor targeted delivery of NPs. In addition, the review article more specifically describes important considerations in the formulation of chitosan nanoparticles such as particle size, shape, stiffness and deformability.
AB - Nanomedicine has recently emerged as an efficient way of overcoming various limitations of conventional medicine, such as a lack of selectivity, poor pharmacokinetics and undesirable side effects. Especially, nanoparticles (NPs) technology has attracted more attentions in nanomedicine based approaches for cancer therapy due to unique physicochemical properties. Although NPs have been intensively studied for tumor targeting and showed some promising results, there is still limited understanding about pharmacokinetic (PK) and pharmacodynamic (PD) properties and tumor targeting efficiency of NPs. Thus, advances in understanding of these issues in NPs technology can create more opportunities to translate nanomedicine approaches into improved clinical outcomes. The goal of this review is to understand the key factors that are required for tumor targeted delivery of NPs. In addition, the review article more specifically describes important considerations in the formulation of chitosan nanoparticles such as particle size, shape, stiffness and deformability.
KW - Cancer targeting
KW - Chitosan nanoparticle
KW - Nanomedicine
KW - Targeted drug delivery
UR - http://www.scopus.com/inward/record.url?scp=84875241723&partnerID=8YFLogxK
U2 - 10.1016/j.cossms.2013.01.002
DO - 10.1016/j.cossms.2013.01.002
M3 - Review article
AN - SCOPUS:84875241723
SN - 1359-0286
VL - 16
SP - 333
EP - 342
JO - Current Opinion in Solid State and Materials Science
JF - Current Opinion in Solid State and Materials Science
IS - 6
ER -
