Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer

Soyeon Jeong; Min Jee Jo; Hye Kyeong Yun; Dae Yeong Kim; Bo Ram Kim; Jung Lim Kim; Seong Hye Park; Yoo Jin Na; Yoon A. Jeong; Bu Gyeom Kim; Hassan Ashktorab; Duane T. Smoot; Jun Young Heo; Jeongsu Han; Sun Il Lee; Han Do Kim; Dae Hyun Kim; Sang Cheul Oh; Dae Hee Lee

doi:10.1038/s41419-019-2001-7

Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer

Soyeon Jeong, Min Jee Jo, Hye Kyeong Yun, Dae Yeong Kim, Bo Ram Kim, Jung Lim Kim, Seong Hye Park, Yoo Jin Na, Yoon A. Jeong, Bu Gyeom Kim, Hassan Ashktorab, Duane T. Smoot, Jun Young Heo, Jeongsu Han, Sun Il Lee, Han Do Kim, Dae Hyun Kim, Sang Cheul Oh, Dae Hee Lee

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

According to recent studies, Cannabidiol (CBD), one of the main components of Cannabis sativa, has anticancer effects in several cancers. However, the exact mechanism of CBD action is not currently understood. Here, CBD promoted cell death in gastric cancer. We suggest that CBD induced apoptosis by suppressing X-linked inhibitor apoptosis (XIAP), a member of the IAP protein family. CBD reduced XIAP protein levels while increasing ubiquitination of XIAP. The expression of Smac, a known inhibitor of XIAP, was found to be elevated during CBD treatment. Moreover, CBD treatment increased the interaction between XIAP and Smac by increasing Smac release from mitochondria to the cytosol. CBD has also been shown to affect mitochondrial dysfunction. Taken together, these results suggest that CBD may have potential as a new therapeutic target in gastric cancer.

Original language	English
Article number	846
Journal	Cell Death and Disease
Volume	10
Issue number	11
DOIs	https://doi.org/10.1038/s41419-019-2001-7
Publication status	Published - 2019 Nov 1

ASJC Scopus subject areas

Immunology
Cellular and Molecular Neuroscience
Cell Biology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41419-019-2001-7

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Jeong, S., Jo, M. J., Yun, H. K., Kim, D. Y., Kim, B. R., Kim, J. L., Park, S. H., Na, Y. J., Jeong, Y. A., Kim, B. G., Ashktorab, H., Smoot, D. T., Heo, J. Y., Han, J., Il Lee, S., Do Kim, H., Kim, D. H., Oh, S. C., & Lee, D. H. (2019). Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer. Cell Death and Disease, 10(11), [846]. https://doi.org/10.1038/s41419-019-2001-7

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title = "Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer",

abstract = "According to recent studies, Cannabidiol (CBD), one of the main components of Cannabis sativa, has anticancer effects in several cancers. However, the exact mechanism of CBD action is not currently understood. Here, CBD promoted cell death in gastric cancer. We suggest that CBD induced apoptosis by suppressing X-linked inhibitor apoptosis (XIAP), a member of the IAP protein family. CBD reduced XIAP protein levels while increasing ubiquitination of XIAP. The expression of Smac, a known inhibitor of XIAP, was found to be elevated during CBD treatment. Moreover, CBD treatment increased the interaction between XIAP and Smac by increasing Smac release from mitochondria to the cytosol. CBD has also been shown to affect mitochondrial dysfunction. Taken together, these results suggest that CBD may have potential as a new therapeutic target in gastric cancer.",

author = "Soyeon Jeong and Jo, {Min Jee} and Yun, {Hye Kyeong} and Kim, {Dae Yeong} and Kim, {Bo Ram} and Kim, {Jung Lim} and Park, {Seong Hye} and Na, {Yoo Jin} and Jeong, {Yoon A.} and Kim, {Bu Gyeom} and Hassan Ashktorab and Smoot, {Duane T.} and Heo, {Jun Young} and Jeongsu Han and {Il Lee}, Sun and {Do Kim}, Han and Kim, {Dae Hyun} and Oh, {Sang Cheul} and Lee, {Dae Hee}",

note = "Funding Information: This work was supported by the Business for Cooperative R & D between Industry, Academy, and Research Institute funded Korea Small and Medium Business Administration in 20 (C0566291), and was supported by a National Research Foundation (NRF) of Korea grant funded by the Korean government (MSIP) (NRF-2017R1A2B2011684) and (NRF-2017R1D1A1B03030703). Moreover, we thank Dr. Hassan Ashktorab and Duane T. Smoot for providing the gastric epithelial HFE-145 cell line. Publisher Copyright: {\textcopyright} 2019, The Author(s).",

year = "2019",

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doi = "10.1038/s41419-019-2001-7",

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T1 - Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer

AU - Jeong, Soyeon

AU - Jo, Min Jee

AU - Yun, Hye Kyeong

AU - Kim, Dae Yeong

AU - Kim, Bo Ram

AU - Kim, Jung Lim

AU - Park, Seong Hye

AU - Na, Yoo Jin

AU - Jeong, Yoon A.

AU - Kim, Bu Gyeom

AU - Ashktorab, Hassan

AU - Smoot, Duane T.

AU - Heo, Jun Young

AU - Han, Jeongsu

AU - Il Lee, Sun

AU - Do Kim, Han

AU - Kim, Dae Hyun

AU - Oh, Sang Cheul

AU - Lee, Dae Hee

N1 - Funding Information: This work was supported by the Business for Cooperative R & D between Industry, Academy, and Research Institute funded Korea Small and Medium Business Administration in 20 (C0566291), and was supported by a National Research Foundation (NRF) of Korea grant funded by the Korean government (MSIP) (NRF-2017R1A2B2011684) and (NRF-2017R1D1A1B03030703). Moreover, we thank Dr. Hassan Ashktorab and Duane T. Smoot for providing the gastric epithelial HFE-145 cell line. Publisher Copyright: © 2019, The Author(s).

PY - 2019/11/1

Y1 - 2019/11/1

N2 - According to recent studies, Cannabidiol (CBD), one of the main components of Cannabis sativa, has anticancer effects in several cancers. However, the exact mechanism of CBD action is not currently understood. Here, CBD promoted cell death in gastric cancer. We suggest that CBD induced apoptosis by suppressing X-linked inhibitor apoptosis (XIAP), a member of the IAP protein family. CBD reduced XIAP protein levels while increasing ubiquitination of XIAP. The expression of Smac, a known inhibitor of XIAP, was found to be elevated during CBD treatment. Moreover, CBD treatment increased the interaction between XIAP and Smac by increasing Smac release from mitochondria to the cytosol. CBD has also been shown to affect mitochondrial dysfunction. Taken together, these results suggest that CBD may have potential as a new therapeutic target in gastric cancer.

AB - According to recent studies, Cannabidiol (CBD), one of the main components of Cannabis sativa, has anticancer effects in several cancers. However, the exact mechanism of CBD action is not currently understood. Here, CBD promoted cell death in gastric cancer. We suggest that CBD induced apoptosis by suppressing X-linked inhibitor apoptosis (XIAP), a member of the IAP protein family. CBD reduced XIAP protein levels while increasing ubiquitination of XIAP. The expression of Smac, a known inhibitor of XIAP, was found to be elevated during CBD treatment. Moreover, CBD treatment increased the interaction between XIAP and Smac by increasing Smac release from mitochondria to the cytosol. CBD has also been shown to affect mitochondrial dysfunction. Taken together, these results suggest that CBD may have potential as a new therapeutic target in gastric cancer.

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Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer

Abstract

ASJC Scopus subject areas

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