CAPE (caffeic acid phenethyl ester) stimulates glucose uptake through AMPK (AMP-activated protein kinase) activation in skeletal muscle cells

Eun Soo Lee; Kyung Ok Uhm; Yun Mi Lee; Myung Suk Han; Myung Sik Lee; Ji Man Park; Pann Ghill Suh; Sun Hwa Park; Hyeon Soo Kim

doi:10.1016/j.bbrc.2007.07.068

CAPE (caffeic acid phenethyl ester) stimulates glucose uptake through AMPK (AMP-activated protein kinase) activation in skeletal muscle cells

Eun Soo Lee, Kyung Ok Uhm, Yun Mi Lee, Myung Suk Han, Myung Sik Lee, Ji Man Park, Pann Ghill Suh, Sun Hwa Park, Hyeon Soo Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Abstract

Caffeic acid phenethyl ester (CAPE), a flavonoid-like compound, is one of the major components of honeybee propolis. In the present study, we investigated the metabolic effects of CAPE in skeletal muscle cells and found that CAPE stimulated glucose uptake in differentiated L6 rat myoblast cells and also activated AMPK (AMP-activated protein kinase). In addition, the inhibition of AMPK blocked CAPE-induced glucose uptake, and CAPE activated the Akt pathway in a PI3K (phosphoinositide 3-kinase)-dependent manner. Furthermore, CAPE enhanced both insulin-mediated Akt activation and glucose uptake. In summary, our results suggest that CAPE may have beneficial roles in glucose metabolism via stimulation of the AMPK pathway.

Original language	English
Pages (from-to)	854-858
Number of pages	5
Journal	Biochemical and biophysical research communications
Volume	361
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2007.07.068
Publication status	Published - 2007 Oct 5

Bibliographical note

Funding Information:
This study was supported by a grant from Korea University college of Medicine. We declare that there is no conflict of interests.

Keywords

AMPK
Akt
CAPE
Glucose uptake

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2007.07.068

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Lee, E. S., Uhm, K. O., Lee, Y. M., Han, M. S., Lee, M. S., Park, J. M., Suh, P. G., Park, S. H., & Kim, H. S. (2007). CAPE (caffeic acid phenethyl ester) stimulates glucose uptake through AMPK (AMP-activated protein kinase) activation in skeletal muscle cells. Biochemical and biophysical research communications, 361(4), 854-858. https://doi.org/10.1016/j.bbrc.2007.07.068

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title = "CAPE (caffeic acid phenethyl ester) stimulates glucose uptake through AMPK (AMP-activated protein kinase) activation in skeletal muscle cells",

abstract = "Caffeic acid phenethyl ester (CAPE), a flavonoid-like compound, is one of the major components of honeybee propolis. In the present study, we investigated the metabolic effects of CAPE in skeletal muscle cells and found that CAPE stimulated glucose uptake in differentiated L6 rat myoblast cells and also activated AMPK (AMP-activated protein kinase). In addition, the inhibition of AMPK blocked CAPE-induced glucose uptake, and CAPE activated the Akt pathway in a PI3K (phosphoinositide 3-kinase)-dependent manner. Furthermore, CAPE enhanced both insulin-mediated Akt activation and glucose uptake. In summary, our results suggest that CAPE may have beneficial roles in glucose metabolism via stimulation of the AMPK pathway.",

keywords = "AMPK, Akt, CAPE, Glucose uptake",

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note = "Funding Information: This study was supported by a grant from Korea University college of Medicine. We declare that there is no conflict of interests.",

year = "2007",

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doi = "10.1016/j.bbrc.2007.07.068",

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T1 - CAPE (caffeic acid phenethyl ester) stimulates glucose uptake through AMPK (AMP-activated protein kinase) activation in skeletal muscle cells

AU - Lee, Eun Soo

AU - Uhm, Kyung Ok

AU - Lee, Yun Mi

AU - Han, Myung Suk

AU - Lee, Myung Sik

AU - Park, Ji Man

AU - Suh, Pann Ghill

AU - Park, Sun Hwa

AU - Kim, Hyeon Soo

N1 - Funding Information: This study was supported by a grant from Korea University college of Medicine. We declare that there is no conflict of interests.

PY - 2007/10/5

Y1 - 2007/10/5

N2 - Caffeic acid phenethyl ester (CAPE), a flavonoid-like compound, is one of the major components of honeybee propolis. In the present study, we investigated the metabolic effects of CAPE in skeletal muscle cells and found that CAPE stimulated glucose uptake in differentiated L6 rat myoblast cells and also activated AMPK (AMP-activated protein kinase). In addition, the inhibition of AMPK blocked CAPE-induced glucose uptake, and CAPE activated the Akt pathway in a PI3K (phosphoinositide 3-kinase)-dependent manner. Furthermore, CAPE enhanced both insulin-mediated Akt activation and glucose uptake. In summary, our results suggest that CAPE may have beneficial roles in glucose metabolism via stimulation of the AMPK pathway.

AB - Caffeic acid phenethyl ester (CAPE), a flavonoid-like compound, is one of the major components of honeybee propolis. In the present study, we investigated the metabolic effects of CAPE in skeletal muscle cells and found that CAPE stimulated glucose uptake in differentiated L6 rat myoblast cells and also activated AMPK (AMP-activated protein kinase). In addition, the inhibition of AMPK blocked CAPE-induced glucose uptake, and CAPE activated the Akt pathway in a PI3K (phosphoinositide 3-kinase)-dependent manner. Furthermore, CAPE enhanced both insulin-mediated Akt activation and glucose uptake. In summary, our results suggest that CAPE may have beneficial roles in glucose metabolism via stimulation of the AMPK pathway.

KW - AMPK

KW - Akt

KW - CAPE

KW - Glucose uptake

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DO - 10.1016/j.bbrc.2007.07.068

M3 - Article

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AN - SCOPUS:34547945472

SN - 0006-291X

VL - 361

SP - 854

EP - 858

JO - Biochemical and biophysical research communications

JF - Biochemical and biophysical research communications

IS - 4

ER -

CAPE (caffeic acid phenethyl ester) stimulates glucose uptake through AMPK (AMP-activated protein kinase) activation in skeletal muscle cells

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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