Carbetapentane attenuates kainate-induced seizures via σ-1 receptor modulation

Hyoung Chun Kim; Wang Kee Jhoo; Won Ki Kim; Eun Joo Shin; Mi Ae Cheon; Chan Young Shin; Kwang Ho Ko

doi:10.1016/S0024-3205(01)01181-X

Carbetapentane attenuates kainate-induced seizures via σ-1 receptor modulation

Hyoung Chun Kim, Wang Kee Jhoo, Won Ki Kim, Eun Joo Shin, Mi Ae Cheon, Chan Young Shin, Kwang Ho Ko

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

We examined the effects of a non-opioid antitussive, carbetapentane (CB) on kainic acid (KA)-induced neurotoxicity in rats. KA administration (10 mg/kg, i.p.) produced robust behavioral convulsions lasting 4 to 5 h. CB (12.5 and 25 mg/kg, i.p.) pretreatment consistently and in a dose-dependent manner reduced the KA-induced seizures, mortality, and marked loss of cells in regions CA1 and CA3 of the hippocampus. Consistently, CB pretreatment also significantly attenuated the KA-induced increase in Fos-related antigen immunoreactivity in the hippocampus. In contrast, pretreatment with the σ-1 receptor antagonist BD1047 (1 and 2 mg/kg, i.p.) blocked, in a dose-related manner, the neuroprotection afforded by CB. These results suggest that CB provides neuroprotection against KA insult via σ-1 receptor modulation.

Original language	English
Pages (from-to)	915-922
Number of pages	8
Journal	Life Sciences
Volume	69
Issue number	8
DOIs	https://doi.org/10.1016/S0024-3205(01)01181-X
Publication status	Published - 2001 Jul 13
Externally published	Yes

Keywords

Anticonvulsant
Carbetapentane
Fos-related antigen immunoreactivity
Hippocampus
Kainic acid
Neuroprotection
Seizures
σ-1 receptor

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/S0024-3205(01)01181-X

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title = "Carbetapentane attenuates kainate-induced seizures via σ-1 receptor modulation",

abstract = "We examined the effects of a non-opioid antitussive, carbetapentane (CB) on kainic acid (KA)-induced neurotoxicity in rats. KA administration (10 mg/kg, i.p.) produced robust behavioral convulsions lasting 4 to 5 h. CB (12.5 and 25 mg/kg, i.p.) pretreatment consistently and in a dose-dependent manner reduced the KA-induced seizures, mortality, and marked loss of cells in regions CA1 and CA3 of the hippocampus. Consistently, CB pretreatment also significantly attenuated the KA-induced increase in Fos-related antigen immunoreactivity in the hippocampus. In contrast, pretreatment with the σ-1 receptor antagonist BD1047 (1 and 2 mg/kg, i.p.) blocked, in a dose-related manner, the neuroprotection afforded by CB. These results suggest that CB provides neuroprotection against KA insult via σ-1 receptor modulation.",

keywords = "Anticonvulsant, Carbetapentane, Fos-related antigen immunoreactivity, Hippocampus, Kainic acid, Neuroprotection, Seizures, σ-1 receptor",

author = "Kim, {Hyoung Chun} and Jhoo, {Wang Kee} and Kim, {Won Ki} and Shin, {Eun Joo} and Cheon, {Mi Ae} and Shin, {Chan Young} and Ko, {Kwang Ho}",

year = "2001",

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T1 - Carbetapentane attenuates kainate-induced seizures via σ-1 receptor modulation

AU - Kim, Hyoung Chun

AU - Jhoo, Wang Kee

AU - Kim, Won Ki

AU - Shin, Eun Joo

AU - Cheon, Mi Ae

AU - Shin, Chan Young

AU - Ko, Kwang Ho

PY - 2001/7/13

Y1 - 2001/7/13

N2 - We examined the effects of a non-opioid antitussive, carbetapentane (CB) on kainic acid (KA)-induced neurotoxicity in rats. KA administration (10 mg/kg, i.p.) produced robust behavioral convulsions lasting 4 to 5 h. CB (12.5 and 25 mg/kg, i.p.) pretreatment consistently and in a dose-dependent manner reduced the KA-induced seizures, mortality, and marked loss of cells in regions CA1 and CA3 of the hippocampus. Consistently, CB pretreatment also significantly attenuated the KA-induced increase in Fos-related antigen immunoreactivity in the hippocampus. In contrast, pretreatment with the σ-1 receptor antagonist BD1047 (1 and 2 mg/kg, i.p.) blocked, in a dose-related manner, the neuroprotection afforded by CB. These results suggest that CB provides neuroprotection against KA insult via σ-1 receptor modulation.

AB - We examined the effects of a non-opioid antitussive, carbetapentane (CB) on kainic acid (KA)-induced neurotoxicity in rats. KA administration (10 mg/kg, i.p.) produced robust behavioral convulsions lasting 4 to 5 h. CB (12.5 and 25 mg/kg, i.p.) pretreatment consistently and in a dose-dependent manner reduced the KA-induced seizures, mortality, and marked loss of cells in regions CA1 and CA3 of the hippocampus. Consistently, CB pretreatment also significantly attenuated the KA-induced increase in Fos-related antigen immunoreactivity in the hippocampus. In contrast, pretreatment with the σ-1 receptor antagonist BD1047 (1 and 2 mg/kg, i.p.) blocked, in a dose-related manner, the neuroprotection afforded by CB. These results suggest that CB provides neuroprotection against KA insult via σ-1 receptor modulation.

KW - Anticonvulsant

KW - Carbetapentane

KW - Fos-related antigen immunoreactivity

KW - Hippocampus

KW - Kainic acid

KW - Neuroprotection

KW - Seizures

KW - σ-1 receptor

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AN - SCOPUS:0035854389

SN - 0024-3205

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JO - Life Sciences

JF - Life Sciences

IS - 8

ER -

Carbetapentane attenuates kainate-induced seizures via σ-1 receptor modulation

Abstract

Keywords

ASJC Scopus subject areas

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