Carbon nanotube monolayer patterns for directed growth of mesenchymal stem cells

Sung Young Park; Sun Young Park; Seon Namgung; Byeongju Kim; Jiwoon Im; Ji Youn Kim; Kyung Sun; Kyu Back Lee; Jwa Min Nam; Yongdoo Park; Seunghun Hong

doi:10.1002/adma.200600875

Carbon nanotube monolayer patterns for directed growth of mesenchymal stem cells

Sung Young Park, Sun Young Park, Seon Namgung, Byeongju Kim, Jiwoon Im, Ji Youn Kim, Kyung Sun, Kyu Back Lee, Jwa Min Nam, Yongdoo Park, Seunghun Hong

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

A novel approach of using self-assembled monolayer (SAM) patterns of carbon nanotubes/nanowires as an efficient means to control the adhesion and shape of mesenchymal stem cells (MSN) has been proposed. The SAM patterns were used to direct the assembly of single-walled CNTs (swCNTs) and multi-walled CNTs (mwCNTs) on solid substrates. A self-limiting mechanism ensured the assembly of only a single layer of CNTs without significant change of surface morphology. The MSCs exhibited preferential growth on CNT patterns, and it was also observed that the CNT patterns did not have a harmful effect on the MSCs. High density swCNT patterns between electrodes were also fabricated to demonstrate the growth of MSCs on the electrodes. The development of directed MSC growth on patterned CNTs offers opportunities to use these nanostructure-based surface arrays as high-throughput cell assay tools and as functional scaffolds for tailoring the MSCs' environment to induce the desired stem cell morphology.

Original language	English
Pages (from-to)	2530-2534
Number of pages	5
Journal	Advanced Materials
Volume	19
Issue number	18
DOIs	https://doi.org/10.1002/adma.200600875
Publication status	Published - 2007 Sept 17

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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title = "Carbon nanotube monolayer patterns for directed growth of mesenchymal stem cells",

abstract = "A novel approach of using self-assembled monolayer (SAM) patterns of carbon nanotubes/nanowires as an efficient means to control the adhesion and shape of mesenchymal stem cells (MSN) has been proposed. The SAM patterns were used to direct the assembly of single-walled CNTs (swCNTs) and multi-walled CNTs (mwCNTs) on solid substrates. A self-limiting mechanism ensured the assembly of only a single layer of CNTs without significant change of surface morphology. The MSCs exhibited preferential growth on CNT patterns, and it was also observed that the CNT patterns did not have a harmful effect on the MSCs. High density swCNT patterns between electrodes were also fabricated to demonstrate the growth of MSCs on the electrodes. The development of directed MSC growth on patterned CNTs offers opportunities to use these nanostructure-based surface arrays as high-throughput cell assay tools and as functional scaffolds for tailoring the MSCs' environment to induce the desired stem cell morphology.",

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AU - Park, Sung Young

AU - Park, Sun Young

AU - Namgung, Seon

AU - Kim, Byeongju

AU - Im, Jiwoon

AU - Kim, Ji Youn

AU - Sun, Kyung

AU - Lee, Kyu Back

AU - Nam, Jwa Min

AU - Park, Yongdoo

AU - Hong, Seunghun

PY - 2007/9/17

Y1 - 2007/9/17

N2 - A novel approach of using self-assembled monolayer (SAM) patterns of carbon nanotubes/nanowires as an efficient means to control the adhesion and shape of mesenchymal stem cells (MSN) has been proposed. The SAM patterns were used to direct the assembly of single-walled CNTs (swCNTs) and multi-walled CNTs (mwCNTs) on solid substrates. A self-limiting mechanism ensured the assembly of only a single layer of CNTs without significant change of surface morphology. The MSCs exhibited preferential growth on CNT patterns, and it was also observed that the CNT patterns did not have a harmful effect on the MSCs. High density swCNT patterns between electrodes were also fabricated to demonstrate the growth of MSCs on the electrodes. The development of directed MSC growth on patterned CNTs offers opportunities to use these nanostructure-based surface arrays as high-throughput cell assay tools and as functional scaffolds for tailoring the MSCs' environment to induce the desired stem cell morphology.

AB - A novel approach of using self-assembled monolayer (SAM) patterns of carbon nanotubes/nanowires as an efficient means to control the adhesion and shape of mesenchymal stem cells (MSN) has been proposed. The SAM patterns were used to direct the assembly of single-walled CNTs (swCNTs) and multi-walled CNTs (mwCNTs) on solid substrates. A self-limiting mechanism ensured the assembly of only a single layer of CNTs without significant change of surface morphology. The MSCs exhibited preferential growth on CNT patterns, and it was also observed that the CNT patterns did not have a harmful effect on the MSCs. High density swCNT patterns between electrodes were also fabricated to demonstrate the growth of MSCs on the electrodes. The development of directed MSC growth on patterned CNTs offers opportunities to use these nanostructure-based surface arrays as high-throughput cell assay tools and as functional scaffolds for tailoring the MSCs' environment to induce the desired stem cell morphology.

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ER -

Carbon nanotube monolayer patterns for directed growth of mesenchymal stem cells

Abstract

ASJC Scopus subject areas

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