Carbonic anhydrase for CO2 capture, conversion and utilization

Sachin Talekar; Byung Hoon Jo; Jonathan S. Dordick; Jungbae Kim

doi:10.1016/j.copbio.2021.12.003

Carbonic anhydrase for CO₂ capture, conversion and utilization

Sachin Talekar, Byung Hoon Jo, Jonathan S. Dordick, Jungbae Kim

Research output: Contribution to journal › Review article › peer-review

93 Citations (Scopus)

Abstract

Carbonic anhydrase (CA) enzymes, catalyzing the CO₂ hydration at a high turnover number, can be employed in expediting CO₂ capture, conversion and utilization to aid in carbon neutrality. Despite extensive research over the last decade, there remain challenges in CA-related technologies due to poor stability and suboptimal use of CAs. Herein, we discuss recent advances in CA stabilization by protein engineering and enzyme immobilization, and shed light on state-of-the-art of in vitro and in vivo CA-mediated CO₂ conversion for improved production of value-added chemicals using CO₂ as a feedstock.

Original language	English
Pages (from-to)	230-240
Number of pages	11
Journal	Current Opinion in Biotechnology
Volume	74
DOIs	https://doi.org/10.1016/j.copbio.2021.12.003
Publication status	Published - 2022 Apr

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Ltd

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering

Access to Document

10.1016/j.copbio.2021.12.003

Cite this

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title = "Carbonic anhydrase for CO2 capture, conversion and utilization",

abstract = "Carbonic anhydrase (CA) enzymes, catalyzing the CO2 hydration at a high turnover number, can be employed in expediting CO2 capture, conversion and utilization to aid in carbon neutrality. Despite extensive research over the last decade, there remain challenges in CA-related technologies due to poor stability and suboptimal use of CAs. Herein, we discuss recent advances in CA stabilization by protein engineering and enzyme immobilization, and shed light on state-of-the-art of in vitro and in vivo CA-mediated CO2 conversion for improved production of value-added chemicals using CO2 as a feedstock.",

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AU - Talekar, Sachin

AU - Jo, Byung Hoon

AU - Dordick, Jonathan S.

AU - Kim, Jungbae

PY - 2022/4

Y1 - 2022/4

N2 - Carbonic anhydrase (CA) enzymes, catalyzing the CO2 hydration at a high turnover number, can be employed in expediting CO2 capture, conversion and utilization to aid in carbon neutrality. Despite extensive research over the last decade, there remain challenges in CA-related technologies due to poor stability and suboptimal use of CAs. Herein, we discuss recent advances in CA stabilization by protein engineering and enzyme immobilization, and shed light on state-of-the-art of in vitro and in vivo CA-mediated CO2 conversion for improved production of value-added chemicals using CO2 as a feedstock.

AB - Carbonic anhydrase (CA) enzymes, catalyzing the CO2 hydration at a high turnover number, can be employed in expediting CO2 capture, conversion and utilization to aid in carbon neutrality. Despite extensive research over the last decade, there remain challenges in CA-related technologies due to poor stability and suboptimal use of CAs. Herein, we discuss recent advances in CA stabilization by protein engineering and enzyme immobilization, and shed light on state-of-the-art of in vitro and in vivo CA-mediated CO2 conversion for improved production of value-added chemicals using CO2 as a feedstock.

UR - https://www.scopus.com/pages/publications/85122161685

U2 - 10.1016/j.copbio.2021.12.003

DO - 10.1016/j.copbio.2021.12.003

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JO - Current Opinion in Biotechnology

JF - Current Opinion in Biotechnology

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