Cardiorenal syndrome

Myung Gyu Kim

    Research output: Contribution to journalArticlepeer-review


    To maintain homeostasis of the cardiovascular system, the heart and kidney act bidirectionally. Therefore, acute or chronic dysfunction of one organ can cause dysfunction in the other. This phenomenon is characterized as cardiorenal syndrome (CRS). Concurrent dysfunction of the heart and kidney adversely affects one another and eventually worsens patient outcomes through a vicious cycle. Although a CRS classification system has been proposed, the underlying pathophysiology is multifactorial and clinical access continues to be difficult. Although several therapies, including agents that target the renin-angiotensin-aldosterone system, have been utilized, there is not enough evidence to demonstrate their effectiveness for CRS. Thus, more effort should be made to optimize the diagnosis and treatment strategies for CRS patients. This review will introduce CRS as it is currently understood, discuss the pathophysiology, and examine management strategies.

    Original languageEnglish
    Pages (from-to)20-29
    Number of pages10
    JournalJournal of the Korean Medical Association
    Issue number1
    Publication statusPublished - 2020 Jan 1

    Bibliographical note

    Publisher Copyright:
    © Korean Medical Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Copyright 2020 Elsevier B.V., All rights reserved.


    • Acute kidney injury
    • Cardio-renal syndrome
    • Chronic renal insufficiency
    • Heart failure

    ASJC Scopus subject areas

    • General Medicine


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