@article{615b7fe79fa349f4b632d50aaff42ef6,
title = "Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo",
abstract = "Caseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated cell and zebrafish model. As a potential anti-inflammatory agent, the anti-inflammatory mechanism of 1 was also investigated.",
keywords = "Anti-inflammation, Casearia kurzii, Homotriterpenoid, Molecular docking, Zebrafish model",
author = "Lijun An and Jun Ma and Xueyuan Yang and Yue Liang and Huimei Wang and Muhetaer Tuerhong and Namrita Lall and Munira Abudukeremu and Yi Zhang and Dongho Lee and Jing Xu and Xiaohui Wu and Yuanqiang Guo",
note = "Funding Information: This research was supported financially by the National Key Research and Development Program of China (No. 2018YFA0507204 ), the National Natural Science Foundation of China (Nos. U1703107 , U1801288 , and 21665013 ), the Natural Science Foundation of Tianjin , China (No. 19JCYBJC28100 ), Hundred Young Academic Leaders Program of Nankai University , and State Key Laboratory of Bioactive Substance and Function of Natural Medicines (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , No. GTZK201902 ). Funding Information: This research was supported financially by the National Key Research and Development Program of China (No. 2018YFA0507204), the National Natural Science Foundation of China (Nos. U1703107, U1801288, and 21665013), the Natural Science Foundation of Tianjin, China (No. 19JCYBJC28100), Hundred Young Academic Leaders Program of Nankai University, and State Key Laboratory of Bioactive Substance and Function of Natural Medicines (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No. GTZK201902). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = may,
doi = "10.1016/j.bioorg.2020.103758",
language = "English",
volume = "98",
journal = "Bioorganic Chemistry",
issn = "0045-2068",
publisher = "Academic Press Inc.",
}