Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo

Lijun An, Jun Ma, Xueyuan Yang, Yue Liang, Huimei Wang, Muhetaer Tuerhong, Namrita Lall, Munira Abudukeremu, Yi Zhang, Dongho Lee, Jing Xu, Xiaohui Wu, Yuanqiang Guo

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Caseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated cell and zebrafish model. As a potential anti-inflammatory agent, the anti-inflammatory mechanism of 1 was also investigated.

    Original languageEnglish
    Article number103758
    JournalBioorganic Chemistry
    Volume98
    DOIs
    Publication statusPublished - 2020 May

    Bibliographical note

    Publisher Copyright:
    © 2020 Elsevier Inc.

    Keywords

    • Anti-inflammation
    • Casearia kurzii
    • Homotriterpenoid
    • Molecular docking
    • Zebrafish model

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Drug Discovery
    • Organic Chemistry

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