Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo

Lijun An; Jun Ma; Xueyuan Yang; Yue Liang; Huimei Wang; Muhetaer Tuerhong; Namrita Lall; Munira Abudukeremu; Yi Zhang; Dongho Lee; Jing Xu; Xiaohui Wu; Yuanqiang Guo

doi:10.1016/j.bioorg.2020.103758

Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo

Lijun An
, Jun Ma
, Xueyuan Yang
, Yue Liang
, Huimei Wang
, Muhetaer Tuerhong
, Namrita Lall
, Munira Abudukeremu
, Yi Zhang
, Dongho Lee
, Jing Xu^*
, Xiaohui Wu
, Yuanqiang Guo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Caseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated cell and zebrafish model. As a potential anti-inflammatory agent, the anti-inflammatory mechanism of 1 was also investigated.

Original language	English
Article number	103758
Journal	Bioorganic Chemistry
Volume	98
DOIs	https://doi.org/10.1016/j.bioorg.2020.103758
Publication status	Published - 2020 May

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

Anti-inflammation
Casearia kurzii
Homotriterpenoid
Molecular docking
Zebrafish model

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Drug Discovery
Organic Chemistry

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10.1016/j.bioorg.2020.103758

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title = "Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo",

abstract = "Caseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated cell and zebrafish model. As a potential anti-inflammatory agent, the anti-inflammatory mechanism of 1 was also investigated.",

keywords = "Anti-inflammation, Casearia kurzii, Homotriterpenoid, Molecular docking, Zebrafish model",

author = "Lijun An and Jun Ma and Xueyuan Yang and Yue Liang and Huimei Wang and Muhetaer Tuerhong and Namrita Lall and Munira Abudukeremu and Yi Zhang and Dongho Lee and Jing Xu and Xiaohui Wu and Yuanqiang Guo",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = may,

doi = "10.1016/j.bioorg.2020.103758",

language = "English",

volume = "98",

journal = "Bioorganic Chemistry",

issn = "0045-2068",

publisher = "Academic Press Inc.",

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TY - JOUR

T1 - Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo

AU - An, Lijun

AU - Ma, Jun

AU - Yang, Xueyuan

AU - Liang, Yue

AU - Wang, Huimei

AU - Tuerhong, Muhetaer

AU - Lall, Namrita

AU - Abudukeremu, Munira

AU - Zhang, Yi

AU - Lee, Dongho

AU - Xu, Jing

AU - Wu, Xiaohui

AU - Guo, Yuanqiang

PY - 2020/5

Y1 - 2020/5

N2 - Caseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated cell and zebrafish model. As a potential anti-inflammatory agent, the anti-inflammatory mechanism of 1 was also investigated.

AB - Caseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated cell and zebrafish model. As a potential anti-inflammatory agent, the anti-inflammatory mechanism of 1 was also investigated.

KW - Anti-inflammation

KW - Casearia kurzii

KW - Homotriterpenoid

KW - Molecular docking

KW - Zebrafish model

UR - https://www.scopus.com/pages/publications/85082433633

U2 - 10.1016/j.bioorg.2020.103758

DO - 10.1016/j.bioorg.2020.103758

M3 - Article

C2 - 32213365

AN - SCOPUS:85082433633

SN - 0045-2068

VL - 98

JO - Bioorganic Chemistry

JF - Bioorganic Chemistry

M1 - 103758

ER -

Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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