Cathepsin B-sensitive nanoprobe for in vivo tumor diagnosis

Ju Hee Ryu; Sun Ah Kim; Heebeom Koo; Ji Young Yhee; Aeju Lee; Jin Hee Na; Inchan Youn; Kuiwon Choi; Ick Chan Kwon; Byung Soo Kim; Kwangmeyung Kim

doi:10.1039/c1jm13064a

Cathepsin B-sensitive nanoprobe for in vivo tumor diagnosis

Ju Hee Ryu, Sun Ah Kim, Heebeom Koo, Ji Young Yhee, Aeju Lee, Jin Hee Na, Inchan Youn, Kuiwon Choi, Ick Chan Kwon, Byung Soo Kim, Kwangmeyung Kim

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

We developed a cathepsin B-sensitive nanoprobe (CB-NP) with a cathepsin B substrate peptide probe and tumor-targeting glycol chitosan nanoparticles. The CB-NP could accumulate in tumor tissues, enter into tumor cells, and generate fluorescent signals in cytosol in response to cathepsin B. The results of non-invasive fluorescence imaging in a tumor-bearing mouse model demonstrated the potential of CB-NP for tumor diagnosis in clinical fields.

Original language	English
Pages (from-to)	17631-17634
Number of pages	4
Journal	Journal of Materials Chemistry
Volume	21
Issue number	44
DOIs	https://doi.org/10.1039/c1jm13064a
Publication status	Published - 2011 Nov 28

ASJC Scopus subject areas

General Chemistry
Materials Chemistry

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10.1039/c1jm13064a

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title = "Cathepsin B-sensitive nanoprobe for in vivo tumor diagnosis",

abstract = "We developed a cathepsin B-sensitive nanoprobe (CB-NP) with a cathepsin B substrate peptide probe and tumor-targeting glycol chitosan nanoparticles. The CB-NP could accumulate in tumor tissues, enter into tumor cells, and generate fluorescent signals in cytosol in response to cathepsin B. The results of non-invasive fluorescence imaging in a tumor-bearing mouse model demonstrated the potential of CB-NP for tumor diagnosis in clinical fields.",

author = "Ryu, {Ju Hee} and Kim, {Sun Ah} and Heebeom Koo and Yhee, {Ji Young} and Aeju Lee and Na, {Jin Hee} and Inchan Youn and Kuiwon Choi and Kwon, {Ick Chan} and Kim, {Byung Soo} and Kwangmeyung Kim",

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T1 - Cathepsin B-sensitive nanoprobe for in vivo tumor diagnosis

AU - Ryu, Ju Hee

AU - Kim, Sun Ah

AU - Koo, Heebeom

AU - Yhee, Ji Young

AU - Lee, Aeju

AU - Na, Jin Hee

AU - Youn, Inchan

AU - Choi, Kuiwon

AU - Kwon, Ick Chan

AU - Kim, Byung Soo

AU - Kim, Kwangmeyung

PY - 2011/11/28

Y1 - 2011/11/28

N2 - We developed a cathepsin B-sensitive nanoprobe (CB-NP) with a cathepsin B substrate peptide probe and tumor-targeting glycol chitosan nanoparticles. The CB-NP could accumulate in tumor tissues, enter into tumor cells, and generate fluorescent signals in cytosol in response to cathepsin B. The results of non-invasive fluorescence imaging in a tumor-bearing mouse model demonstrated the potential of CB-NP for tumor diagnosis in clinical fields.

AB - We developed a cathepsin B-sensitive nanoprobe (CB-NP) with a cathepsin B substrate peptide probe and tumor-targeting glycol chitosan nanoparticles. The CB-NP could accumulate in tumor tissues, enter into tumor cells, and generate fluorescent signals in cytosol in response to cathepsin B. The results of non-invasive fluorescence imaging in a tumor-bearing mouse model demonstrated the potential of CB-NP for tumor diagnosis in clinical fields.

UR - http://www.scopus.com/inward/record.url?scp=80455163253&partnerID=8YFLogxK

U2 - 10.1039/c1jm13064a

DO - 10.1039/c1jm13064a

M3 - Article

AN - SCOPUS:80455163253

SN - 0959-9428

VL - 21

SP - 17631

EP - 17634

JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

IS - 44

ER -

Cathepsin B-sensitive nanoprobe for in vivo tumor diagnosis

Abstract

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