CD1-restricted T-cell responses and microbial infection

Se Ho Park; Albert Bendelac

doi:10.1038/35021233

CD1-restricted T-cell responses and microbial infection

Se Ho Park^*, Albert Bendelac

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

107 Citations (Scopus)

Abstract

CD1, a conserved family of major histocompatibility (MHC)-like glycoproteins in mammals, specializes in capturing lipid rather than peptide antigen for presentation to T lymphocytes. The principles and mechanisms of this newly discovered immune strategy differ markedly from those governing classical MHC-peptide presentation. They might be exploited for the design of new lipid-based microbial vaccines and adjuvants.

Original language	English
Pages (from-to)	788-792
Number of pages	5
Journal	Nature
Volume	406
Issue number	6797
DOIs	https://doi.org/10.1038/35021233
Publication status	Published - 2000 Aug 17
Externally published	Yes

ASJC Scopus subject areas

General

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/35021233

Cite this

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title = "CD1-restricted T-cell responses and microbial infection",

abstract = "CD1, a conserved family of major histocompatibility (MHC)-like glycoproteins in mammals, specializes in capturing lipid rather than peptide antigen for presentation to T lymphocytes. The principles and mechanisms of this newly discovered immune strategy differ markedly from those governing classical MHC-peptide presentation. They might be exploited for the design of new lipid-based microbial vaccines and adjuvants.",

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T1 - CD1-restricted T-cell responses and microbial infection

AU - Park, Se Ho

AU - Bendelac, Albert

PY - 2000/8/17

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N2 - CD1, a conserved family of major histocompatibility (MHC)-like glycoproteins in mammals, specializes in capturing lipid rather than peptide antigen for presentation to T lymphocytes. The principles and mechanisms of this newly discovered immune strategy differ markedly from those governing classical MHC-peptide presentation. They might be exploited for the design of new lipid-based microbial vaccines and adjuvants.

AB - CD1, a conserved family of major histocompatibility (MHC)-like glycoproteins in mammals, specializes in capturing lipid rather than peptide antigen for presentation to T lymphocytes. The principles and mechanisms of this newly discovered immune strategy differ markedly from those governing classical MHC-peptide presentation. They might be exploited for the design of new lipid-based microbial vaccines and adjuvants.

UR - https://www.scopus.com/pages/publications/0034680109

U2 - 10.1038/35021233

DO - 10.1038/35021233

M3 - Review article

C2 - 10963609

AN - SCOPUS:0034680109

SN - 0028-0836

VL - 406

SP - 788

EP - 792

JO - Nature

JF - Nature

IS - 6797

ER -

CD1-restricted T-cell responses and microbial infection

Abstract

ASJC Scopus subject areas

UN SDGs

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