CD36 is required for myoblast fusion during myogenic differentiation

Seung Yoon Park; Youngeun Yun; In San Kim

doi:10.1016/j.bbrc.2012.09.119

CD36 is required for myoblast fusion during myogenic differentiation

Seung Yoon Park
, Youngeun Yun
, In San Kim^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Recently, CD36 has been found to be involved in the cytokine-induced fusion of macrophage. Myoblast fusion to form multinucleated myotubes is required for myogenesis and muscle regeneration. Because a search of gene expression database revealed the attenuation of CD36 expression in the muscles of muscular dystrophy patients, the possibility that CD36 could be required for myoblast fusion was investigated. CD36 expression was markedly up-regulated during myoblast differentiation and localized in multinucleated myotubes. Knockdown of endogenous CD36 significantly decreased the expression of myogenic markers as well as myotube formation. These results support the notion that CD36 plays an important role in cell fusion during myogenic differentiation. Our finding will aid the elucidation of the common mechanism governing cell-to-cell fusion in various fusion models.

Original language	English
Pages (from-to)	705-710
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	427
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2012.09.119
Publication status	Published - 2012 Nov 2
Externally published	Yes

Bibliographical note

Funding Information:
This study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology ( 2010-0021626 , 2011-0016102 ); by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) ( 2010-0029206 ); by the Converging Research Center Program through the Ministry of Education, Science, and Technology ( 2010K001054 ); and by the Brain Korea 21 Project .

Keywords

CD36
Cell fusion
Myoblast fusion
Myogenic differentiation
Skeletal muscle

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2012.09.119

Cite this

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title = "CD36 is required for myoblast fusion during myogenic differentiation",

abstract = "Recently, CD36 has been found to be involved in the cytokine-induced fusion of macrophage. Myoblast fusion to form multinucleated myotubes is required for myogenesis and muscle regeneration. Because a search of gene expression database revealed the attenuation of CD36 expression in the muscles of muscular dystrophy patients, the possibility that CD36 could be required for myoblast fusion was investigated. CD36 expression was markedly up-regulated during myoblast differentiation and localized in multinucleated myotubes. Knockdown of endogenous CD36 significantly decreased the expression of myogenic markers as well as myotube formation. These results support the notion that CD36 plays an important role in cell fusion during myogenic differentiation. Our finding will aid the elucidation of the common mechanism governing cell-to-cell fusion in various fusion models.",

keywords = "CD36, Cell fusion, Myoblast fusion, Myogenic differentiation, Skeletal muscle",

author = "Park, \{Seung Yoon\} and Youngeun Yun and Kim, \{In San\}",

note = "Funding Information: This study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology ( 2010-0021626 , 2011-0016102 ); by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) ( 2010-0029206 ); by the Converging Research Center Program through the Ministry of Education, Science, and Technology ( 2010K001054 ); and by the Brain Korea 21 Project . ",

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doi = "10.1016/j.bbrc.2012.09.119",

language = "English",

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AU - Park, Seung Yoon

AU - Yun, Youngeun

AU - Kim, In San

N1 - Funding Information: This study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology ( 2010-0021626 , 2011-0016102 ); by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) ( 2010-0029206 ); by the Converging Research Center Program through the Ministry of Education, Science, and Technology ( 2010K001054 ); and by the Brain Korea 21 Project .

PY - 2012/11/2

Y1 - 2012/11/2

N2 - Recently, CD36 has been found to be involved in the cytokine-induced fusion of macrophage. Myoblast fusion to form multinucleated myotubes is required for myogenesis and muscle regeneration. Because a search of gene expression database revealed the attenuation of CD36 expression in the muscles of muscular dystrophy patients, the possibility that CD36 could be required for myoblast fusion was investigated. CD36 expression was markedly up-regulated during myoblast differentiation and localized in multinucleated myotubes. Knockdown of endogenous CD36 significantly decreased the expression of myogenic markers as well as myotube formation. These results support the notion that CD36 plays an important role in cell fusion during myogenic differentiation. Our finding will aid the elucidation of the common mechanism governing cell-to-cell fusion in various fusion models.

AB - Recently, CD36 has been found to be involved in the cytokine-induced fusion of macrophage. Myoblast fusion to form multinucleated myotubes is required for myogenesis and muscle regeneration. Because a search of gene expression database revealed the attenuation of CD36 expression in the muscles of muscular dystrophy patients, the possibility that CD36 could be required for myoblast fusion was investigated. CD36 expression was markedly up-regulated during myoblast differentiation and localized in multinucleated myotubes. Knockdown of endogenous CD36 significantly decreased the expression of myogenic markers as well as myotube formation. These results support the notion that CD36 plays an important role in cell fusion during myogenic differentiation. Our finding will aid the elucidation of the common mechanism governing cell-to-cell fusion in various fusion models.

KW - CD36

KW - Cell fusion

KW - Myoblast fusion

KW - Myogenic differentiation

KW - Skeletal muscle

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U2 - 10.1016/j.bbrc.2012.09.119

DO - 10.1016/j.bbrc.2012.09.119

M3 - Article

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AN - SCOPUS:84868214640

SN - 0006-291X

VL - 427

SP - 705

EP - 710

JO - Biochemical and biophysical research communications

JF - Biochemical and biophysical research communications

IS - 4

ER -

CD36 is required for myoblast fusion during myogenic differentiation

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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