CD74 expression is increased in high-grade, invasive urothelial carcinoma of the bladder

Jung Woo Choi, Younghye Kim, Ju Han Lee, Young Sik Kim

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


This study aimed to identify the clinicopathological features of bladder cancer patients with high CD74 expression, as milatuzumab humanized anti-CD74 antibody is being evaluated in clinical trials for hematological malignancies. Expression of CD74 was examined in 342 urothelial carcinomas of the bladder, and two urothelial carcinoma cell lines by immunohistochemistry and western blotting, respectively. CD74 was overexpressed in 192 (56.1%) of the 342 cancer tissues, although it was not expressed in the cancer cell lines. CD74 staining was intense in tumor cells and inflammatory cells in the tumor stroma, but not in normal urothelium. CD74 expression was significantly associated with older age at diagnosis (≥68years, P=0.048), high World Health Organization grade (P=0.019), advanced stages (P=0.001) and non-papillary growth pattern (P=0.040). CD74 expression was also correlated with the absence of tumor-infiltrating inflammatory cells (P<0.001) and the presence of tumor-associated inflammatory cells (P=0.017). However, CD74 expression was not related to recurrence-free and overall survivals in primary and subgroup analyses. In conclusion, urothelial bladder carcinomas with high CD74 expression are characterized by older age, high World Health Organization grade, non-papillary growth and advanced stages.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalInternational Journal of Urology
Issue number2
Publication statusPublished - 2013 Feb


  • Bladder
  • CD74
  • Immunohistochemistry
  • Macrophage migration inhibitory factor receptor
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Urology


Dive into the research topics of 'CD74 expression is increased in high-grade, invasive urothelial carcinoma of the bladder'. Together they form a unique fingerprint.

Cite this