@inproceedings{16825a7129c145a2be3094cdbea8f1d9,
title = "Cellular internalization of a membrane binding two-photon probe by a complex of anionic diblock copolymer and cationic surfactant",
abstract = "We report a two-photon (TP) absorbing molecular probe 1,4-bis(4'-(N,N- bis(6''-(N,N,N-trimethylammonium)hexyl)amino)-styryl)benzene tetrabromide (C1) and its interaction with cells upon encapsulation with polymeric vesicles. Two-photon microscopy (TPM) revealed that the free C1 specifically could bind to the plasma membrane and shows bright TP emission. However, C1 encapsulated with polymeric vesicles internalized into the cytosol. In addition, fluorescence quantum efficiency and TP cross section of encapsulated C1 enhanced by 2-fold. These results not only show useful guidelines for the development of efficient TP probes, but also underscore the possibility of using this type of nanostructure for intracellular delivery of the bioactive therapeutics.",
keywords = "Cellular internalization, Nanocarrier, Polymeric vesicles, Two-photon microscopy",
author = "Nag, {Okhil Kumar} and Woo, {Han Young} and Chen, {Wei R.}",
year = "2012",
doi = "10.1117/12.901836",
language = "English",
isbn = "9780819488671",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Biophotonics and Immune Responses VII",
note = "Biophotonics and Immune Responses VII ; Conference date: 23-01-2012 Through 23-01-2012",
}