We prepared five folate-conjugated lipophilic superparamagnetic iron oxide nanoparticles (F5-Liposuperparamagnetic iron oxide nanoparticles(SPIONs), 5.5 and 11 nm) and investigated their cellular uptake with KB cells, which is one of the representative folate-receptor over-expressing human epidermoid carcinoma cells, using MRI. The cellular uptake tests with the respective 5.5 and 11 nm F5-LipoSPIONs at a fixed particle concentration showed appreciable amount of receptor-mediated uptakes and the specificity was higher in 5.5 nm SPIONs, due to its higher folic acid (FA) density, without inhibition. However, the numbers of the particles taken up under FA inhibition were similar, irrespective of their sizes.
Bibliographical noteFunding Information:
The authors are thankful for financial support from the Korean Ministry of Education, Science and Technology through Grant no. 2007-02502 of the “Nano R&D Program” and “Future Key Technology Program”.
- Cellular uptake
- Surface modification
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics