TY - JOUR
T1 - Central Nervous System and its Disease Models on a Chip
AU - Yi, Yoon Young
AU - Park, Ji Soo
AU - Lim, Jaeho
AU - Lee, C. Justin
AU - Lee, Sang Hoon
N1 - Funding Information:
This work was supported by the National Research Foundation of Korea ( NRF-2015R1A2A1A09004998 ), Korea.
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/12
Y1 - 2015/12
N2 - Technologies for microfluidics and biological microelectromechanical systems have been rapidly progressing over the past decade, enabling the development of unique microplatforms for in vitro human central nervous system (CNS) and related disease models. Most fundamental techniques include manipulation of axons, synapses, and neuronal networks, and different culture conditions are possible, such as compartmental, co-culturing, and 3D. Various CNS disease models, such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), epilepsy, N-methyl-D-aspartate receptor (NMDAR) encephalitis, migraine, diffuse axonal injury, and neuronal migration disorders, have been successfully established on microplatforms. In this review, we summarize fundamental technologies and current existing CNS disease models on microplatforms. We also discuss possible future directions, including application of these methods to pathological studies, drug screening, and personalized medicine, with 3D and personalized disease models that could generate more realistic CNS disease models. Various microplatforms mimicking in vivo microenvironments of central nervous system (CNS) are reviewed.In vitro CNS disease models, including Alzheimer's disease, Parkinson's disease, and so on, using microplatforms are introduced.Future directions of in vitro CNS disease model based on microplatforms are described, including its application to pathology studies, drug screening, and personalized medicine.
AB - Technologies for microfluidics and biological microelectromechanical systems have been rapidly progressing over the past decade, enabling the development of unique microplatforms for in vitro human central nervous system (CNS) and related disease models. Most fundamental techniques include manipulation of axons, synapses, and neuronal networks, and different culture conditions are possible, such as compartmental, co-culturing, and 3D. Various CNS disease models, such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), epilepsy, N-methyl-D-aspartate receptor (NMDAR) encephalitis, migraine, diffuse axonal injury, and neuronal migration disorders, have been successfully established on microplatforms. In this review, we summarize fundamental technologies and current existing CNS disease models on microplatforms. We also discuss possible future directions, including application of these methods to pathological studies, drug screening, and personalized medicine, with 3D and personalized disease models that could generate more realistic CNS disease models. Various microplatforms mimicking in vivo microenvironments of central nervous system (CNS) are reviewed.In vitro CNS disease models, including Alzheimer's disease, Parkinson's disease, and so on, using microplatforms are introduced.Future directions of in vitro CNS disease model based on microplatforms are described, including its application to pathology studies, drug screening, and personalized medicine.
KW - Brain
KW - CNS
KW - Microfluidics
KW - Neural disease
KW - Organ-on-a-chip
UR - http://www.scopus.com/inward/record.url?scp=84947909246&partnerID=8YFLogxK
U2 - 10.1016/j.tibtech.2015.09.007
DO - 10.1016/j.tibtech.2015.09.007
M3 - Review article
C2 - 26497426
AN - SCOPUS:84947909246
SN - 0167-7799
VL - 33
SP - 762
EP - 776
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 12
ER -