Cerebellar atrophy in patients with subcortical-type vascular cognitive impairment

Cindy W. Yoon; Sang Won Seo; Jun Sung Park; Ki Chang Kwak; Uicheul Yoon; Mee Kyung Suh; Geon Ha Kim; Ji Soo Shin; Chi Hun Kim; Young Noh; Hanna Cho; Min Jeong Kim; Jong Hun Kim; Jee Hoon Roh; Jong Min Lee; Duk L. Na

doi:10.1007/s12311-012-0388-0

Cerebellar atrophy in patients with subcortical-type vascular cognitive impairment

Cindy W. Yoon, Sang Won Seo, Jun Sung Park, Ki Chang Kwak, Uicheul Yoon, Mee Kyung Suh, Geon Ha Kim, Ji Soo Shin, Chi Hun Kim, Young Noh, Hanna Cho, Min Jeong Kim, Jong Hun Kim, Jee Hoon Roh, Jong Min Lee, Duk L. Na

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Recent studies suggest that the role of the cerebellum extends into cognitive regulation and that subcortical vascular dementia (SVaD) can result in cerebellar atrophy. However, there has been no evaluation of the cerebellar volume in the preclinical stage of SVaD. We aimed to compare cerebellar volume among patients with amnestic mild cognitive impairment (aMCI) and subcortical vascular mild cognitive impairment (svMCI) and evaluate which factors could have contributed to the cerebellar volume. Participants were composed of 355 patients with aMCI, svMCI, Alzheimer's disease (AD), and SVaD. Cerebellar volumes were measured using automated methods. A direct comparison of the cerebellar volume in SVaD and AD groups showed that the SVaD group had a statistically smaller cerebellar volume than the AD group. Additionally, the svMCI group had a smaller cerebellar volume than the aMCI group, with the number of lacunes (especially in the supratentorial regions) being associated with cerebellar volume. Cerebellar volumes were associated with some neuropsychological tests, digit span backward and ideomotor apraxia. These findings suggest that cerebellar atrophy may be useful in differentiating subtypes of dementia and the cerebellum plays a potential role in cognition.

Original language	English
Pages (from-to)	35-42
Number of pages	8
Journal	Cerebellum
Volume	12
Issue number	1
DOIs	https://doi.org/10.1007/s12311-012-0388-0
Publication status	Published - 2013 Feb
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgments This study was supported by a grant from the Korean Healthcare Technology R&D Project; Ministry for Health, Welfare and Family Affairs, Republic of Korea (A102065 & A070001); a Korean Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean government (MEST; R0A-2007-000-20068-0); and a Samsung Medical Center Clinical Research Development Program grant (CRL-108011 & CRS 110-14-1).

Keywords

Cerebellar atrophy
Lacunes
Subcortical vascular MCI
White matter hyperintensities

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Cerebellar atrophy in patients with subcortical-type vascular cognitive impairment",

abstract = "Recent studies suggest that the role of the cerebellum extends into cognitive regulation and that subcortical vascular dementia (SVaD) can result in cerebellar atrophy. However, there has been no evaluation of the cerebellar volume in the preclinical stage of SVaD. We aimed to compare cerebellar volume among patients with amnestic mild cognitive impairment (aMCI) and subcortical vascular mild cognitive impairment (svMCI) and evaluate which factors could have contributed to the cerebellar volume. Participants were composed of 355 patients with aMCI, svMCI, Alzheimer's disease (AD), and SVaD. Cerebellar volumes were measured using automated methods. A direct comparison of the cerebellar volume in SVaD and AD groups showed that the SVaD group had a statistically smaller cerebellar volume than the AD group. Additionally, the svMCI group had a smaller cerebellar volume than the aMCI group, with the number of lacunes (especially in the supratentorial regions) being associated with cerebellar volume. Cerebellar volumes were associated with some neuropsychological tests, digit span backward and ideomotor apraxia. These findings suggest that cerebellar atrophy may be useful in differentiating subtypes of dementia and the cerebellum plays a potential role in cognition.",

keywords = "Cerebellar atrophy, Lacunes, Subcortical vascular MCI, White matter hyperintensities",

author = "Yoon, {Cindy W.} and Seo, {Sang Won} and Park, {Jun Sung} and Kwak, {Ki Chang} and Uicheul Yoon and Suh, {Mee Kyung} and Kim, {Geon Ha} and Shin, {Ji Soo} and Kim, {Chi Hun} and Young Noh and Hanna Cho and Kim, {Min Jeong} and Kim, {Jong Hun} and Roh, {Jee Hoon} and Lee, {Jong Min} and Na, {Duk L.}",

note = "Funding Information: Acknowledgments This study was supported by a grant from the Korean Healthcare Technology R&D Project; Ministry for Health, Welfare and Family Affairs, Republic of Korea (A102065 & A070001); a Korean Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean government (MEST; R0A-2007-000-20068-0); and a Samsung Medical Center Clinical Research Development Program grant (CRL-108011 & CRS 110-14-1).",

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AU - Yoon, Uicheul

AU - Suh, Mee Kyung

AU - Kim, Geon Ha

AU - Shin, Ji Soo

AU - Kim, Chi Hun

AU - Noh, Young

AU - Cho, Hanna

AU - Kim, Min Jeong

AU - Kim, Jong Hun

AU - Roh, Jee Hoon

AU - Lee, Jong Min

AU - Na, Duk L.

N1 - Funding Information: Acknowledgments This study was supported by a grant from the Korean Healthcare Technology R&D Project; Ministry for Health, Welfare and Family Affairs, Republic of Korea (A102065 & A070001); a Korean Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean government (MEST; R0A-2007-000-20068-0); and a Samsung Medical Center Clinical Research Development Program grant (CRL-108011 & CRS 110-14-1).

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N2 - Recent studies suggest that the role of the cerebellum extends into cognitive regulation and that subcortical vascular dementia (SVaD) can result in cerebellar atrophy. However, there has been no evaluation of the cerebellar volume in the preclinical stage of SVaD. We aimed to compare cerebellar volume among patients with amnestic mild cognitive impairment (aMCI) and subcortical vascular mild cognitive impairment (svMCI) and evaluate which factors could have contributed to the cerebellar volume. Participants were composed of 355 patients with aMCI, svMCI, Alzheimer's disease (AD), and SVaD. Cerebellar volumes were measured using automated methods. A direct comparison of the cerebellar volume in SVaD and AD groups showed that the SVaD group had a statistically smaller cerebellar volume than the AD group. Additionally, the svMCI group had a smaller cerebellar volume than the aMCI group, with the number of lacunes (especially in the supratentorial regions) being associated with cerebellar volume. Cerebellar volumes were associated with some neuropsychological tests, digit span backward and ideomotor apraxia. These findings suggest that cerebellar atrophy may be useful in differentiating subtypes of dementia and the cerebellum plays a potential role in cognition.

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Cerebellar atrophy in patients with subcortical-type vascular cognitive impairment

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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