Cerebral hemodynamic monitoring of Parkinson's disease patients with orthostatic intolerance during head-up tilt test

Jung Bin Kim, Zephaniah Phillips, Seung Ho Paik, Shin Young Kang, Nam Joon Jeon, Byung Jo Kim, Beop Min Kim

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Significance: Monitoring of cerebral perfusion rather than blood pressure changes during a head-up tilt test (HUTT) is proposed to understand the pathophysiological effect of orthostatic intolerance (OI), including orthostatic hypotension (OH), in Parkinson's disease (PD) patients. Aim: We aim to characterize and distinguish the cerebral perfusion response to a HUTT for healthy controls (HCs) and PD patients with OI symptoms. Approach: Thirty-nine PD patients with OI symptoms [10 PD patients with OH (PD-OH) and 29 PD patients with normal HUTT results (PD-NOR)], along with seven HCs participated. A 108-channel diffuse optical tomography (DOT) system was used to reconstruct prefrontal oxyhemoglobin (HbO), deoxyhemoglobin (Hb), and total hemoglobin (HbT) changes during dynamic tilt (from supine to 70-deg tilt) and static tilt (remained tilted at 70 deg). Results: HCs showed rapid recovery of cerebral perfusion in the early stages of static tilt. PD-OH patients showed decreasing HbO and HbT during dynamic tilt, continuing into the static tilt period. The rate of HbO change from dynamic tilt to static tilt is the distinguishing feature between HCs and PD-OH patients. Accordingly, PD-NOR patients were subgrouped based on positive-rate and negative-rate of HbO change. PD patients with a negative rate of HbO change were more likely to report severe OI symptoms in the COMPASS questionnaire. Conclusions: Our findings showcase the usability of DOT for sensitive detection and quantification of autonomic dysfunction in PD patients with OI symptoms, even those with normal HUTT results.

Original languageEnglish
Article number025002
Issue number2
Publication statusPublished - 2020 Apr 1


  • Parkinson's disease
  • autonomic dysfunction
  • diffuse optical tomography
  • head-up tilt
  • orthostatic hypotension

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Cerebral hemodynamic monitoring of Parkinson's disease patients with orthostatic intolerance during head-up tilt test'. Together they form a unique fingerprint.

Cite this