Ceria Nanoparticles Fabricated with 6-Aminohexanoic Acid that Overcome Systemic Inflammatory Response Syndrome

Han Gil Jeong, Bong Geun Cha, Dong Wan Kang, Do Yeon Kim, Wookjin Yang, Seul Ki Ki, Song I. Kim, Juhee Han, Chi Kyung Kim, Jaeyun Kim, Seung Hoon Lee

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Systemic inflammatory response syndrome (SIRS) is self-destructive and uncontrollable inflammatory response of the whole body triggered by infection, trauma, or a variety of severe injuries. Although reactive oxygen species play a pivotal role in the development of SIRS, the trials with conventional antioxidants have failed to improve patient outcome. Ceria nanoparticles (CeNPs) have potent, autocatalytic reactive oxygen species scavenging activities, which may have sufficient therapeutic effects for SIRS. Herein, 3 nm CeNPs are fabricated totally in aqueous phase by using 6-aminohexanoic acid (6-AHA) and their Ce3+ to Ce4+ ratio is increased to enhance antioxidative properties. The obtained 6-AHA-CeNPs demonstrate strong antioxidative and anti-inflammatory effects in various biofluids and inflammatory cells. In SIRS animal models, 6-AHA-CeNPs are demonstrated to reduce multiple organ injuries and inflammation. Moreover, 6-AHA-CeNPs decrease mortality and improve clinical scores of SIRS models. These findings suggest that 6-AHA-CeNPs have potential as a therapeutic nanomedicine for SIRS.

Original languageEnglish
Article number1801548
JournalAdvanced Healthcare Materials
Volume8
Issue number9
DOIs
Publication statusPublished - 2019 May 9

Bibliographical note

Funding Information:
H.-G.J. and B.G.C. contributed equally to this work. This research was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea (Grant No. HI17C0076), and the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (Grant Nos. NRF-2018R1A2A2A05022369 and NRF-2010-0027955).

Publisher Copyright:
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • 6-aminohexanoid acid
  • cerium oxide nanoparticles
  • nanotherapeutics
  • reactive oxygen species
  • systemic inflammatory response syndrome

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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