Abstract
Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.
Original language | English |
---|---|
Pages (from-to) | 11039-11043 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 51 |
Issue number | 44 |
DOIs | |
Publication status | Published - 2012 Oct 29 |
Keywords
- apoptosis
- ceria nanoparticles
- ischemic stroke
- reactive oxygen species
- therapeutic agents
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)