Ceria nanoparticles that can protect against ischemic stroke

Chi Kyung Kim, Taeho Kim, In Young Choi, Min Soh, Dohoung Kim, Young Ju Kim, Hyunduk Jang, Hye Sung Yang, Jun Yup Kim, Hong Kyun Park, Seung Pyo Park, Sangseung Park, Taekyung Yu, Byung Woo Yoon, Seung Hoon Lee, Taeghwan Hyeon

    Research output: Contribution to journalArticlepeer-review

    513 Citations (Scopus)

    Abstract

    Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.

    Original languageEnglish
    Pages (from-to)11039-11043
    Number of pages5
    JournalAngewandte Chemie - International Edition
    Volume51
    Issue number44
    DOIs
    Publication statusPublished - 2012 Oct 29

    Keywords

    • apoptosis
    • ceria nanoparticles
    • ischemic stroke
    • reactive oxygen species
    • therapeutic agents

    ASJC Scopus subject areas

    • Catalysis
    • General Chemistry

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