Ceria nanoparticles that can protect against ischemic stroke

Chi Kyung Kim; Taeho Kim; In Young Choi; Min Soh; Dohoung Kim; Young Ju Kim; Hyunduk Jang; Hye Sung Yang; Jun Yup Kim; Hong Kyun Park; Seung Pyo Park; Sangseung Park; Taekyung Yu; Byung Woo Yoon; Seung Hoon Lee; Taeghwan Hyeon

doi:10.1002/anie.201203780

Ceria nanoparticles that can protect against ischemic stroke

Chi Kyung Kim, Taeho Kim, In Young Choi, Min Soh, Dohoung Kim, Young Ju Kim, Hyunduk Jang, Hye Sung Yang, Jun Yup Kim, Hong Kyun Park, Seung Pyo Park, Sangseung Park, Taekyung Yu, Byung Woo Yoon, Seung Hoon Lee, Taeghwan Hyeon

Research output: Contribution to journal › Article › peer-review

513 Citations (Scopus)

Abstract

Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.

Original language	English
Pages (from-to)	11039-11043
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	44
DOIs	https://doi.org/10.1002/anie.201203780
Publication status	Published - 2012 Oct 29

Keywords

apoptosis
ceria nanoparticles
ischemic stroke
reactive oxygen species
therapeutic agents

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201203780

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title = "Ceria nanoparticles that can protect against ischemic stroke",

abstract = "Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.",

keywords = "apoptosis, ceria nanoparticles, ischemic stroke, reactive oxygen species, therapeutic agents",

author = "Kim, {Chi Kyung} and Taeho Kim and Choi, {In Young} and Min Soh and Dohoung Kim and Kim, {Young Ju} and Hyunduk Jang and Yang, {Hye Sung} and Kim, {Jun Yup} and Park, {Hong Kyun} and Park, {Seung Pyo} and Sangseung Park and Taekyung Yu and Yoon, {Byung Woo} and Lee, {Seung Hoon} and Taeghwan Hyeon",

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T1 - Ceria nanoparticles that can protect against ischemic stroke

AU - Kim, Chi Kyung

AU - Kim, Taeho

AU - Choi, In Young

AU - Soh, Min

AU - Kim, Dohoung

AU - Kim, Young Ju

AU - Jang, Hyunduk

AU - Yang, Hye Sung

AU - Kim, Jun Yup

AU - Park, Hong Kyun

AU - Park, Seung Pyo

AU - Park, Sangseung

AU - Yu, Taekyung

AU - Yoon, Byung Woo

AU - Lee, Seung Hoon

AU - Hyeon, Taeghwan

PY - 2012/10/29

Y1 - 2012/10/29

N2 - Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.

AB - Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.

KW - apoptosis

KW - ceria nanoparticles

KW - ischemic stroke

KW - reactive oxygen species

KW - therapeutic agents

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U2 - 10.1002/anie.201203780

DO - 10.1002/anie.201203780

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SN - 1433-7851

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 44

ER -

Ceria nanoparticles that can protect against ischemic stroke

Abstract

Keywords

ASJC Scopus subject areas

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