Ceria nanoparticles that can protect against ischemic stroke

Chi Kyung Kim; Taeho Kim; In Young Choi; Min Soh; Dohoung Kim; Young Ju Kim; Hyunduk Jang; Hye Sung Yang; Jun Yup Kim; Hong Kyun Park; Seung Pyo Park; Sangseung Park; Taekyung Yu; Byung Woo Yoon; Seung Hoon Lee; Taeghwan Hyeon

doi:10.1002/anie.201203780

Ceria nanoparticles that can protect against ischemic stroke

Chi Kyung Kim
, Taeho Kim
, In Young Choi
, Min Soh
, Dohoung Kim
, Young Ju Kim
, Hyunduk Jang
, Hye Sung Yang
, Jun Yup Kim
, Hong Kyun Park
, Seung Pyo Park
, Sangseung Park
, Taekyung Yu
, Byung Woo Yoon
, Seung Hoon Lee^*
, Taeghwan Hyeon

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

532 Citations (Scopus)

Abstract

Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.

Original language	English
Pages (from-to)	11039-11043
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	44
DOIs	https://doi.org/10.1002/anie.201203780
Publication status	Published - 2012 Oct 29
Externally published	Yes

Keywords

apoptosis
ceria nanoparticles
ischemic stroke
reactive oxygen species
therapeutic agents

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201203780

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title = "Ceria nanoparticles that can protect against ischemic stroke",

abstract = "Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.",

keywords = "apoptosis, ceria nanoparticles, ischemic stroke, reactive oxygen species, therapeutic agents",

author = "Kim, \{Chi Kyung\} and Taeho Kim and Choi, \{In Young\} and Min Soh and Dohoung Kim and Kim, \{Young Ju\} and Hyunduk Jang and Yang, \{Hye Sung\} and Kim, \{Jun Yup\} and Park, \{Hong Kyun\} and Park, \{Seung Pyo\} and Sangseung Park and Taekyung Yu and Yoon, \{Byung Woo\} and Lee, \{Seung Hoon\} and Taeghwan Hyeon",

year = "2012",

month = oct,

day = "29",

doi = "10.1002/anie.201203780",

language = "English",

volume = "51",

pages = "11039--11043",

journal = "Angewandte Chemie - International Edition",

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TY - JOUR

T1 - Ceria nanoparticles that can protect against ischemic stroke

AU - Kim, Chi Kyung

AU - Kim, Taeho

AU - Choi, In Young

AU - Soh, Min

AU - Kim, Dohoung

AU - Kim, Young Ju

AU - Jang, Hyunduk

AU - Yang, Hye Sung

AU - Kim, Jun Yup

AU - Park, Hong Kyun

AU - Park, Seung Pyo

AU - Park, Sangseung

AU - Yu, Taekyung

AU - Yoon, Byung Woo

AU - Lee, Seung Hoon

AU - Hyeon, Taeghwan

PY - 2012/10/29

Y1 - 2012/10/29

N2 - Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.

AB - Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.

KW - apoptosis

KW - ceria nanoparticles

KW - ischemic stroke

KW - reactive oxygen species

KW - therapeutic agents

UR - https://www.scopus.com/pages/publications/84867776377

U2 - 10.1002/anie.201203780

DO - 10.1002/anie.201203780

M3 - Article

C2 - 22968916

AN - SCOPUS:84867776377

SN - 1433-7851

VL - 51

SP - 11039

EP - 11043

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 44

ER -

Ceria nanoparticles that can protect against ischemic stroke

Abstract

Keywords

ASJC Scopus subject areas

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