Change in kidney damage biomarkers after 13weeks of exposing rats to the complex of Paecilomyces sinclairii and its host Bombyx mori larvae

Mihye Jeong, Young Won Kim, Jeong Ran Min, Min Kwon, Beom Suk Han, Jeong Gyu Kim, Sang Hee Jeong

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Complex of Paecilomyces sinclairii and host larvae, Bombyx mori, is a well known health food; however, concerns about nephrotoxicity have been raised. Kidney toxicity was investigated after 13. weeks of administering the complex orally to rats with parameters including blood urea nitrogen (BUN), creatinine, and kidney damage biomarkers, beta-2-microglobulin (β2m), glutathione S-transferase alpha (GST-α), kidney injury molecule 1 (KIM-1), tissue inhibitor of matrix metalloproteinase 1 (TIMP-1), vascular endothelial growth factor (VEGF), calbindin, clusterin, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL), and osteopontin. Dose-dependent kidney cell karyomegaly and tubular hypertrophy were observed, with higher severity in males. There was a dose-dependent increase in KIM-1 and TIMP-1 levels in kidney and urinary KIM-1, cystatin C, β2m, and osteopontin levels. KIM-1 and TIMP-1 increased in male kidneys had not recovered by 2. weeks after stopping exposure. Cystatin C in kidney was significantly lowered in all treatment groups at 13. weeks of administration. All the changes were more noticeable in males. These data indicate that the complex damage renal tubule cells with histopathological lesions and changes in biomarker levels. Kidney and urinary KIM-1 and cystatin C were the most markedly affected and early increased indicators among biomarkers tested, whereas BUN and creatinine were not affected.

    Original languageEnglish
    Pages (from-to)177-186
    Number of pages10
    JournalFood and Chemical Toxicology
    Volume59
    DOIs
    Publication statusPublished - 2013 Sept

    Bibliographical note

    Funding Information:
    This work was supported by a research Grant of the Rural Development Administration Korea in 2011.

    Keywords

    • Bombyx mori larvae
    • Cystatin C
    • Kidney damage biomarkers
    • Kidney injury molecule 1
    • Kidney toxicity
    • Paecilomyces sinclairii

    ASJC Scopus subject areas

    • Food Science
    • Toxicology

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