Changes in erythrocyte aggregation and deformability in diabetes mellitus: A brief review

Megha Singh, Sehyun Shin

Research output: Contribution to journalReview articlepeer-review

93 Citations (Scopus)


Diabetes mellitus (DM) is a metabolic disorder characterized by varying or persistent hyperglycemia either due to insufficient production of insulin by pancreas or improper utilization of the glucose. Erythrocytes remain in hyperglycemic environment throughout their life span and thus are subjected to series of compositional changes, which in turn affect their flow properties through alteration of deformation at individual level and aggregation at collective level. This brief review summarizes the changes in biochemical parameters primarily contributing to the erythrocyte eformability and aggregation as measured by various techniques, of blood samples obtained from diabetic subjects. The significant changes in erythrocyte aggregation and deformability, in comparison with that of control subjects show the relevance of these measurements. These changes are further supported by in vivo observations of blood flow through microvessels. Finally the relevance of these in combination with other clinical param eters is suggested.

Original languageEnglish
Pages (from-to)7-15
Number of pages9
JournalIndian Journal of Experimental Biology
Issue number1
Publication statusPublished - 2009 Jan


  • Deformability
  • Diabetes mellitus
  • Erythrocyte aggregation
  • Techniques

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Cell Biology


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