TY - JOUR
T1 - Changes in N-terminal Pro B-type natriuretic peptide concentration
T2 - Comparative study of percutaneous transluminal coronary angioplasty and off-pump coronary artery bypass graft
AU - Hyun, Koo Kim
AU - Hark, Jei Kim
AU - Kim, Jin Won
AU - Sohn, Young Sang
AU - Young, Ho Choi
PY - 2007/2
Y1 - 2007/2
N2 - The goal of this study was to compare the effects of different reperfusion methods on N-terminal B-type natriuretic peptide (NT-proBNP) in percutaneous transluminal coronary angioplasty (PTCA) or off-pump coronary artery bypass (OPCAB) patients. Fifty subjects were enrolled in the study, 32 patients received PTCA and 18 OPCAB. An NT-proBNP measurement was performed before intervention and at 1, 3, and 7 days after the procedures. NT-proBNP levels were not significantly different before intervention (PTCA group 297±147.3 vs. OPCAB group 235±167.8 pg/mL, p>0.05). However, 1 day after the procedures, NT-proBNP levels were higher in the OPCAB group (PTCA 375±256.4 vs. OPCAB 1,415±737.6 pg/mL, p<0.05), after 3 days NT-proBNP reached peak levels (PTCA 480±363.0 vs. OPCAB 2,119±818.4 pg/mL, p<0.05), and levels were reduced after 7 days (PTCA 292±243.7 vs. OPCAB 522±334.0 pg/mL, p>0.05). PTCA induced a mild and transient increase in NT-proBNP concentration, but OPCAB caused sustained high NT-proBNP levels during the 7 day postoperatively. However, differences between NT-proBNP levels associated with these two modalities showed a tendency to decrease rapidly postoperatively.
AB - The goal of this study was to compare the effects of different reperfusion methods on N-terminal B-type natriuretic peptide (NT-proBNP) in percutaneous transluminal coronary angioplasty (PTCA) or off-pump coronary artery bypass (OPCAB) patients. Fifty subjects were enrolled in the study, 32 patients received PTCA and 18 OPCAB. An NT-proBNP measurement was performed before intervention and at 1, 3, and 7 days after the procedures. NT-proBNP levels were not significantly different before intervention (PTCA group 297±147.3 vs. OPCAB group 235±167.8 pg/mL, p>0.05). However, 1 day after the procedures, NT-proBNP levels were higher in the OPCAB group (PTCA 375±256.4 vs. OPCAB 1,415±737.6 pg/mL, p<0.05), after 3 days NT-proBNP reached peak levels (PTCA 480±363.0 vs. OPCAB 2,119±818.4 pg/mL, p<0.05), and levels were reduced after 7 days (PTCA 292±243.7 vs. OPCAB 522±334.0 pg/mL, p>0.05). PTCA induced a mild and transient increase in NT-proBNP concentration, but OPCAB caused sustained high NT-proBNP levels during the 7 day postoperatively. However, differences between NT-proBNP levels associated with these two modalities showed a tendency to decrease rapidly postoperatively.
KW - Angioplasty, transluminal, percutaneous coronary
KW - Coronary artery bypass, off-pump
KW - Natriuretic peptide, brain
KW - Reperfusion
UR - http://www.scopus.com/inward/record.url?scp=33847156357&partnerID=8YFLogxK
U2 - 10.3346/jkms.2007.22.1.16
DO - 10.3346/jkms.2007.22.1.16
M3 - Article
C2 - 17297245
AN - SCOPUS:33847156357
SN - 1011-8934
VL - 22
SP - 16
EP - 19
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
IS - 1
ER -