Changes in the arginine methylation of organ proteins during the development of diabetes mellitus

Jong Hoon Lee; Gil Hong Park; Young Koo Lee; Jun Hyung Park

doi:10.1016/j.diabres.2011.07.005

Changes in the arginine methylation of organ proteins during the development of diabetes mellitus

Jong Hoon Lee, Gil Hong Park, Young Koo Lee, Jun Hyung Park

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Aim: In this study, we examined changes in asymmetric dimethylarginine (ADMA), dimethylarginine dimethylaminohydrolase (DDAH), nitric oxide synthesis (NOS), and the arginine methylation of organ proteins during the development of diabetes in mice. Methods: Db/db mice developed significant obesity and fasting hyperglycemia during diabetogenesis. During diabetogenesis, the expression of ADMA and nNOS was increased, while that of DDAH1 and protein-arginine methyltransferase 1 (PRMT1) was decreased. Additionally, arginine methylation in the liver and adipose tissue was altered during diabetogenesis. Results: Changes were evident at 75, 60, and 52. kDa in liver tissue and at 38 and 25. kDa in adipose tissue. Collectively, DDAH and ADMA are closely associated with the development of obesity and diabetes, and the arginine methylation levels of certain proteins were changed during diabetes development. Conclusion: Protein arginine methylation plays a role in the pathogenesis of diabetes.

Original language	English
Pages (from-to)	111-118
Number of pages	8
Journal	Diabetes Research and Clinical Practice
Volume	94
Issue number	1
DOIs	https://doi.org/10.1016/j.diabres.2011.07.005
Publication status	Published - 2011 Oct

Keywords

Arginine methylation
Asymmetric dimethylarginine
Diabetes mellitus
Dimethylarginine dimethylaminohydrolase
Nitric oxide synthase

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diabres.2011.07.005

Cite this

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title = "Changes in the arginine methylation of organ proteins during the development of diabetes mellitus",

abstract = "Aim: In this study, we examined changes in asymmetric dimethylarginine (ADMA), dimethylarginine dimethylaminohydrolase (DDAH), nitric oxide synthesis (NOS), and the arginine methylation of organ proteins during the development of diabetes in mice. Methods: Db/db mice developed significant obesity and fasting hyperglycemia during diabetogenesis. During diabetogenesis, the expression of ADMA and nNOS was increased, while that of DDAH1 and protein-arginine methyltransferase 1 (PRMT1) was decreased. Additionally, arginine methylation in the liver and adipose tissue was altered during diabetogenesis. Results: Changes were evident at 75, 60, and 52. kDa in liver tissue and at 38 and 25. kDa in adipose tissue. Collectively, DDAH and ADMA are closely associated with the development of obesity and diabetes, and the arginine methylation levels of certain proteins were changed during diabetes development. Conclusion: Protein arginine methylation plays a role in the pathogenesis of diabetes.",

keywords = "Arginine methylation, Asymmetric dimethylarginine, Diabetes mellitus, Dimethylarginine dimethylaminohydrolase, Nitric oxide synthase",

author = "Lee, {Jong Hoon} and Park, {Gil Hong} and Lee, {Young Koo} and Park, {Jun Hyung}",

year = "2011",

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doi = "10.1016/j.diabres.2011.07.005",

language = "English",

volume = "94",

pages = "111--118",

journal = "Diabetes Research and Clinical Practice",

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T1 - Changes in the arginine methylation of organ proteins during the development of diabetes mellitus

AU - Lee, Jong Hoon

AU - Park, Gil Hong

AU - Lee, Young Koo

AU - Park, Jun Hyung

PY - 2011/10

Y1 - 2011/10

N2 - Aim: In this study, we examined changes in asymmetric dimethylarginine (ADMA), dimethylarginine dimethylaminohydrolase (DDAH), nitric oxide synthesis (NOS), and the arginine methylation of organ proteins during the development of diabetes in mice. Methods: Db/db mice developed significant obesity and fasting hyperglycemia during diabetogenesis. During diabetogenesis, the expression of ADMA and nNOS was increased, while that of DDAH1 and protein-arginine methyltransferase 1 (PRMT1) was decreased. Additionally, arginine methylation in the liver and adipose tissue was altered during diabetogenesis. Results: Changes were evident at 75, 60, and 52. kDa in liver tissue and at 38 and 25. kDa in adipose tissue. Collectively, DDAH and ADMA are closely associated with the development of obesity and diabetes, and the arginine methylation levels of certain proteins were changed during diabetes development. Conclusion: Protein arginine methylation plays a role in the pathogenesis of diabetes.

AB - Aim: In this study, we examined changes in asymmetric dimethylarginine (ADMA), dimethylarginine dimethylaminohydrolase (DDAH), nitric oxide synthesis (NOS), and the arginine methylation of organ proteins during the development of diabetes in mice. Methods: Db/db mice developed significant obesity and fasting hyperglycemia during diabetogenesis. During diabetogenesis, the expression of ADMA and nNOS was increased, while that of DDAH1 and protein-arginine methyltransferase 1 (PRMT1) was decreased. Additionally, arginine methylation in the liver and adipose tissue was altered during diabetogenesis. Results: Changes were evident at 75, 60, and 52. kDa in liver tissue and at 38 and 25. kDa in adipose tissue. Collectively, DDAH and ADMA are closely associated with the development of obesity and diabetes, and the arginine methylation levels of certain proteins were changed during diabetes development. Conclusion: Protein arginine methylation plays a role in the pathogenesis of diabetes.

KW - Arginine methylation

KW - Asymmetric dimethylarginine

KW - Diabetes mellitus

KW - Dimethylarginine dimethylaminohydrolase

KW - Nitric oxide synthase

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Changes in the arginine methylation of organ proteins during the development of diabetes mellitus

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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