Characteristic immunostimulation by angelan isolated from Angelica gigas Nakai

Sang Bae Han, Young Hee Kim, Chang Woo Lee, Sun Mi Park, Hae Young Lee, Kyung Seop Ahn, Ik Hwan Kim, Hwan Mook Kim

Research output: Contribution to journalArticlepeer-review

143 Citations (Scopus)


The immunopharmacological characteristics of angelan, a polysaccharide purified from Angelica gigas Nakai, were investigated in relation to the specificity to immune cells. The treatment of angelan increased the expression of IL-2, IL-4, IL-6, and IFN-γ. The expression of IL-6 and IFN-γ was rapidly augmented but that of IL-2 responded later. In the case of IL-4, angelan stimulated at early time after exposure but down-regulated thereafter. These results suggested that macrophages and natural killer cells involved in nonspecific immunity were primarily activated and helper T cells were secondarily affected by angelan. Angelan also had lympho-proliferative potential to B cells, specifically. The specificity of angelan was also elucidated in a cell fractionation experiment. The activated B cells by angelan also increased antibody production. The direct activation of B cells, macrophages, and accessory cells and the indirect activation of helper T cells coordinately increased immune functions such as in vitro and in vivo T-dependent immunization and antibody production. The experiment of host resistance to syngeneic tumors also showed that angelan potentiated the immune functions. In conclusion, angelan, a purified polysaccharide from an oriental herbal drug, showed characteristic immunostimulation, which was different from clinically used polysaccharides such as lentinan and PSK. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)39-48
Number of pages10
Issue number1
Publication statusPublished - 1998 Jul


  • Angelan
  • Angelica gigas Nakai
  • B cells
  • Immunostimulation
  • Macrophages
  • Specificity

ASJC Scopus subject areas

  • Pharmacology


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