Characteristics of neurocognitive functions in mild cognitive impairment with depression

Hyun Seok Dong, Changsu Han, Sang Won Jeon, Seoyoung Yoon, Hyun Ghang Jeong, Yu Jeong Huh, Chi Un Pae, Ashwin A. Patkar, David C. Steffens

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)


    Background: Previous studies suggest that there is a strong association between depression and cognitive decline, and that concurrent depressive symptoms in MCI patients could contribute to a difference in neurocognitive characteristics compared to MCI patients without depression. The authors tried to compare neurocognitive functions between MCI patients with and without depression by analyzing the results of neuropsychological tests. Methods: Participants included 153 MCI patients. Based on the diagnosis of major depressive disorder, the participants were divided into two groups: depressed MCI (MCI/D+) versus non-depressed MCI (MCI/D-). The general cognitive and functional statuses of participants were evaluated. And a subset of various neuropsychological tests was presented to participants. Demographic and clinical data were analyzed using Student t-test or χ 2 test. Results: A total of 153 participants were divided into two groups: 94 MCI/D+ patients and 59 MCI/D- patients. Age, sex, and years of education were not significantly different between the two groups. There were no significant differences in general cognitive status between MCI/D+ and MCI/D- patients, but MCI/D+ participants showed significantly reduced performance in the six subtests (Contrasting Program, Go-no-go task, Fist-edge-palm task, Constructional Praxis, Memory Recall, TMT-A) compared with MCI/D- patients. Conclusions: There were significantly greater deficits in neurocognitive functions including verbal memory, executive function, attention/processing speed, and visual memory in MCI/D+ participants compared to MCI/D-. Once the biological mechanism is identified, distinct approaches in treatment or prevention will be determined.

    Original languageEnglish
    Pages (from-to)1181-1190
    Number of pages10
    JournalInternational Psychogeriatrics
    Issue number7
    Publication statusPublished - 2016 Jul 1

    Bibliographical note

    Funding Information:
    This study was supported by a grant of the Korean Health Technology RandD Project, Ministry of Health and Welfare, Republic of Korea (A070001)

    Publisher Copyright:
    Copyright © International Psychogeriatric Association 2016.


    • Alzheimer's disease
    • depression
    • mild cognitive impairment
    • neurocognitive function
    • neuropsychology

    ASJC Scopus subject areas

    • Clinical Psychology
    • Gerontology
    • Geriatrics and Gerontology
    • Psychiatry and Mental health


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