Abstract
This paper reports the properties of vitamin C encapsulated sodium alginate beads prepared by an alternative approach. The alternative encapsulation process mainly involves immobilization of vitamin C in hydrated zinc oxide layers and encapsulation of prepared immobilized particles in sodium alginate bead. The immobilization of vitamin C in hydrated zinc oxide layers was achieved by a coprecipitation process. Fourier transform infrared (FTIR) spectroscopy showed that the vitamin C was found to be stable after its immobilization. X-ray diffraction (XRD) studies revealed that anionic vitamin C molecules are adsorbed between positively charged zinc hydroxide layers with a 1:1 layer sequence, since well-defined change in basal spacing was observed. Well-defined change in surface morphology was observed by scanning electron microscopy (SEM) when vitamin C immobilized particles are encapsulated in sodium alginate bead. The biological activity of vitamin C was retained, even after its immobilization which was confirmed by 4-dihydroxy-L-phenylalanine (L-DOPA) oxidase inhibition and free radical scavenging activity studies. The release rate of vitamin C from immobilized particles and beads was sustained through an ion exchange process. A higher amount of stable vitamin C was recovered from the bead when compared to neat vitamin C itself.
Original language | English |
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Pages (from-to) | 363-376 |
Number of pages | 14 |
Journal | Journal of Microencapsulation |
Volume | 22 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2005 Jun |
Bibliographical note
Funding Information:This study was supported by a grant of the Korea Health 21R&D Project, Ministry of Health & Welfare, Republic of Korea (A050376). We also thank the Korea Science and Engineering Foundation (KOSEF) for the financial support.
Keywords
- Bead
- Encapsulation
- Sodium alginate
- Stability
- Sustained release
- Vitamic C
ASJC Scopus subject areas
- Bioengineering
- Pharmaceutical Science
- Physical and Theoretical Chemistry
- Organic Chemistry
- Colloid and Surface Chemistry