Characterization of diterpenoids from Caesalpinia decapetala and their anti-TMV activities

Jing Xu; Xiangrong Cao; Feng Liu; Jun Ma; Xingyu Liu; Ling Tong; Guochen Su; Yasushi Ohizumi; Dongho Lee; Lizhong Wang; Yuanqiang Guo

doi:10.1016/j.fitote.2016.07.017

Characterization of diterpenoids from Caesalpinia decapetala and their anti-TMV activities

Jing Xu, Xiangrong Cao, Feng Liu, Jun Ma, Xingyu Liu, Ling Tong, Guochen Su, Yasushi Ohizumi, Dongho Lee, Lizhong Wang, Yuanqiang Guo

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Caesalpinia decapetala is a versatile medicinal plant belonging to the Fabaceae plant family. In our survey on plant secondary metabolites to obtain bioactive substances for the development of new agricultural anti-TMV agents, the chemical constituents of C. decapetala were investigated. This investigation led to the isolation of three new and ten known diterpenoids. Their structures including absolute configurations were elucidated based on the extensive NMR spectroscopic data analyses and the time-dependent density functional theory calculations. The following biological screenings revealed that most of these diterpenoids possessed anti-TMV activities.

Original language	English
Pages (from-to)	144-150
Number of pages	7
Journal	Fitoterapia
Volume	113
DOIs	https://doi.org/10.1016/j.fitote.2016.07.017
Publication status	Published - 2016 Sept 1

Keywords

Anti-TMV activities
Caesalpinia decapetala
Cassane-type
Diterpenoids
ECD calculations

ASJC Scopus subject areas

Pharmacology
Drug Discovery

Access to Document

10.1016/j.fitote.2016.07.017

Cite this

@article{25644a9a450845a39054fa54c3181d22,

title = "Characterization of diterpenoids from Caesalpinia decapetala and their anti-TMV activities",

abstract = "Caesalpinia decapetala is a versatile medicinal plant belonging to the Fabaceae plant family. In our survey on plant secondary metabolites to obtain bioactive substances for the development of new agricultural anti-TMV agents, the chemical constituents of C. decapetala were investigated. This investigation led to the isolation of three new and ten known diterpenoids. Their structures including absolute configurations were elucidated based on the extensive NMR spectroscopic data analyses and the time-dependent density functional theory calculations. The following biological screenings revealed that most of these diterpenoids possessed anti-TMV activities.",

keywords = "Anti-TMV activities, Caesalpinia decapetala, Cassane-type, Diterpenoids, ECD calculations",

author = "Jing Xu and Xiangrong Cao and Feng Liu and Jun Ma and Xingyu Liu and Ling Tong and Guochen Su and Yasushi Ohizumi and Dongho Lee and Lizhong Wang and Yuanqiang Guo",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (Nos. 21372125 and 81102331 ), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700 ), and the State Key Laboratory of Medicinal Chemical Biology (No. 201602007 ). Publisher Copyright: {\textcopyright} 2016 Elsevier B.V. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2016",

month = sep,

day = "1",

doi = "10.1016/j.fitote.2016.07.017",

language = "English",

volume = "113",

pages = "144--150",

journal = "Fitoterapia",

issn = "0367-326X",

publisher = "Elsevier",

}

TY - JOUR

T1 - Characterization of diterpenoids from Caesalpinia decapetala and their anti-TMV activities

AU - Xu, Jing

AU - Cao, Xiangrong

AU - Liu, Feng

AU - Ma, Jun

AU - Liu, Xingyu

AU - Tong, Ling

AU - Su, Guochen

AU - Ohizumi, Yasushi

AU - Lee, Dongho

AU - Wang, Lizhong

AU - Guo, Yuanqiang

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (Nos. 21372125 and 81102331 ), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700 ), and the State Key Laboratory of Medicinal Chemical Biology (No. 201602007 ). Publisher Copyright: © 2016 Elsevier B.V. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Caesalpinia decapetala is a versatile medicinal plant belonging to the Fabaceae plant family. In our survey on plant secondary metabolites to obtain bioactive substances for the development of new agricultural anti-TMV agents, the chemical constituents of C. decapetala were investigated. This investigation led to the isolation of three new and ten known diterpenoids. Their structures including absolute configurations were elucidated based on the extensive NMR spectroscopic data analyses and the time-dependent density functional theory calculations. The following biological screenings revealed that most of these diterpenoids possessed anti-TMV activities.

AB - Caesalpinia decapetala is a versatile medicinal plant belonging to the Fabaceae plant family. In our survey on plant secondary metabolites to obtain bioactive substances for the development of new agricultural anti-TMV agents, the chemical constituents of C. decapetala were investigated. This investigation led to the isolation of three new and ten known diterpenoids. Their structures including absolute configurations were elucidated based on the extensive NMR spectroscopic data analyses and the time-dependent density functional theory calculations. The following biological screenings revealed that most of these diterpenoids possessed anti-TMV activities.

KW - Anti-TMV activities

KW - Caesalpinia decapetala

KW - Cassane-type

KW - Diterpenoids

KW - ECD calculations

UR - http://www.scopus.com/inward/record.url?scp=84981287542&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84981287542&partnerID=8YFLogxK

U2 - 10.1016/j.fitote.2016.07.017

DO - 10.1016/j.fitote.2016.07.017

M3 - Article

C2 - 27491755

AN - SCOPUS:84981287542

SN - 0367-326X

VL - 113

SP - 144

EP - 150

JO - Fitoterapia

JF - Fitoterapia

ER -

Characterization of diterpenoids from Caesalpinia decapetala and their anti-TMV activities

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this