Characterization of hyaluronic acid-poly(ethylene oxide) hydrogel dependent upon poly(ethylene oxide)

Mi Sook Kim; Yoon Jeong Choi; Gun Woo Kim; Insup Noh; Yongdoo Park; Kyu Back Lee; In Sook Kim; Soon Jung Hwang; Gilwon Yoon

doi:10.4028/0-87849-436-7.749

Characterization of hyaluronic acid-poly(ethylene oxide) hydrogel dependent upon poly(ethylene oxide)

Mi Sook Kim, Yoon Jeong Choi, Gun Woo Kim, Insup Noh, Yongdoo Park, Kyu Back Lee, In Sook Kim, Soon Jung Hwang, Gilwon Yoon

Research output: Contribution to journal › Article › peer-review

Abstract

Characterization of an hyaluronic acid (HA)-poly(ethylene oxide) (PEO) hydrogel was performed by changing the number of side arms in a PEO molecule. Verification of grafting chemistry and mechanical strength, as well as swelling behaviors and surface morphologies of the HA-PEO hydrogels were analyzed by employing different x-linking molecular weights (MW) of PEO ranging from 1.7 to 5.0 kDa at a fixed low MW HA in the hydrogel network. Methacrylation to the HA successfully obtained via Michael type reaction between the methacrylate arm groups in HA and the thiol end groups in PEO was observed by XPS. Hydrogel formation was markedly dependent upon the numbers of thiol groups in the PEO molecule. Furthermore the lower MW PEO-based HA hydrogel demonstrated stronger mechanical properties but lower water absorption and the smaller pore sizes on its surface and cross section.

Original language	English
Pages (from-to)	749-752
Number of pages	4
Journal	Key Engineering Materials
Volume	342-343
DOIs	https://doi.org/10.4028/0-87849-436-7.749
Publication status	Published - 2007

Keywords

Characterization
Hyaluronic acid
In situ hydrogel
Poly(ethylene oxide)

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.4028/0-87849-436-7.749

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title = "Characterization of hyaluronic acid-poly(ethylene oxide) hydrogel dependent upon poly(ethylene oxide)",

abstract = "Characterization of an hyaluronic acid (HA)-poly(ethylene oxide) (PEO) hydrogel was performed by changing the number of side arms in a PEO molecule. Verification of grafting chemistry and mechanical strength, as well as swelling behaviors and surface morphologies of the HA-PEO hydrogels were analyzed by employing different x-linking molecular weights (MW) of PEO ranging from 1.7 to 5.0 kDa at a fixed low MW HA in the hydrogel network. Methacrylation to the HA successfully obtained via Michael type reaction between the methacrylate arm groups in HA and the thiol end groups in PEO was observed by XPS. Hydrogel formation was markedly dependent upon the numbers of thiol groups in the PEO molecule. Furthermore the lower MW PEO-based HA hydrogel demonstrated stronger mechanical properties but lower water absorption and the smaller pore sizes on its surface and cross section.",

keywords = "Characterization, Hyaluronic acid, In situ hydrogel, Poly(ethylene oxide)",

author = "Kim, {Mi Sook} and Choi, {Yoon Jeong} and Kim, {Gun Woo} and Insup Noh and Yongdoo Park and Lee, {Kyu Back} and Kim, {In Sook} and Hwang, {Soon Jung} and Gilwon Yoon",

year = "2007",

doi = "10.4028/0-87849-436-7.749",

language = "English",

volume = "342-343",

pages = "749--752",

journal = "Key Engineering Materials",

issn = "1013-9826",

publisher = "Trans Tech Publications",

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T1 - Characterization of hyaluronic acid-poly(ethylene oxide) hydrogel dependent upon poly(ethylene oxide)

AU - Kim, Mi Sook

AU - Choi, Yoon Jeong

AU - Kim, Gun Woo

AU - Noh, Insup

AU - Park, Yongdoo

AU - Lee, Kyu Back

AU - Kim, In Sook

AU - Hwang, Soon Jung

AU - Yoon, Gilwon

PY - 2007

Y1 - 2007

N2 - Characterization of an hyaluronic acid (HA)-poly(ethylene oxide) (PEO) hydrogel was performed by changing the number of side arms in a PEO molecule. Verification of grafting chemistry and mechanical strength, as well as swelling behaviors and surface morphologies of the HA-PEO hydrogels were analyzed by employing different x-linking molecular weights (MW) of PEO ranging from 1.7 to 5.0 kDa at a fixed low MW HA in the hydrogel network. Methacrylation to the HA successfully obtained via Michael type reaction between the methacrylate arm groups in HA and the thiol end groups in PEO was observed by XPS. Hydrogel formation was markedly dependent upon the numbers of thiol groups in the PEO molecule. Furthermore the lower MW PEO-based HA hydrogel demonstrated stronger mechanical properties but lower water absorption and the smaller pore sizes on its surface and cross section.

AB - Characterization of an hyaluronic acid (HA)-poly(ethylene oxide) (PEO) hydrogel was performed by changing the number of side arms in a PEO molecule. Verification of grafting chemistry and mechanical strength, as well as swelling behaviors and surface morphologies of the HA-PEO hydrogels were analyzed by employing different x-linking molecular weights (MW) of PEO ranging from 1.7 to 5.0 kDa at a fixed low MW HA in the hydrogel network. Methacrylation to the HA successfully obtained via Michael type reaction between the methacrylate arm groups in HA and the thiol end groups in PEO was observed by XPS. Hydrogel formation was markedly dependent upon the numbers of thiol groups in the PEO molecule. Furthermore the lower MW PEO-based HA hydrogel demonstrated stronger mechanical properties but lower water absorption and the smaller pore sizes on its surface and cross section.

KW - Characterization

KW - Hyaluronic acid

KW - In situ hydrogel

KW - Poly(ethylene oxide)

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U2 - 10.4028/0-87849-436-7.749

DO - 10.4028/0-87849-436-7.749

M3 - Article

AN - SCOPUS:34147130863

SN - 1013-9826

VL - 342-343

SP - 749

EP - 752

JO - Key Engineering Materials

JF - Key Engineering Materials

ER -

Characterization of hyaluronic acid-poly(ethylene oxide) hydrogel dependent upon poly(ethylene oxide)

Abstract

Keywords

ASJC Scopus subject areas

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