Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm

Yan Lee; Takehiko Ishii; Horacio Cabral; Hyun Jin Kim; Ji Hun Seo; Nobuhiro Nishiyama; Hiroki Oshima; Kensuke Osada; Kazunori Kataoka

doi:10.1002/anie.200900064

Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm

Yan Lee, Takehiko Ishii, Horacio Cabral, Hyun Jin Kim, Ji Hun Seo, Nobuhiro Nishiyama, Hiroki Oshima, Kensuke Osada, Kazunori Kataoka

Research output: Contribution to journal › Article › peer-review

302 Citations (Scopus)

Abstract

Special delivery! Polyionic complex (PIC) micelles that contain the charge-conversional moieties citaconic amide or cis-aconitic amide were developed for cytoplasmic protein delivery. The increase of the charge density on the protein cargo helped the stability of the PIC micelles without cross-linking, and the charge-conversion in endosomes induced the dissociation of the PIC micelles to result in efficient endosomal release (see picture).

Original language	English
Pages (from-to)	5309-5312
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	29
DOIs	https://doi.org/10.1002/anie.200900064
Publication status	Published - 2009 Jul 6
Externally published	Yes

Keywords

Charge conversion
Cytochromes
Drug delivery
Endosomes
Micelles

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200900064

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abstract = "Special delivery! Polyionic complex (PIC) micelles that contain the charge-conversional moieties citaconic amide or cis-aconitic amide were developed for cytoplasmic protein delivery. The increase of the charge density on the protein cargo helped the stability of the PIC micelles without cross-linking, and the charge-conversion in endosomes induced the dissociation of the PIC micelles to result in efficient endosomal release (see picture).",

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AU - Lee, Yan

AU - Ishii, Takehiko

AU - Cabral, Horacio

AU - Kim, Hyun Jin

AU - Seo, Ji Hun

AU - Nishiyama, Nobuhiro

AU - Oshima, Hiroki

AU - Osada, Kensuke

AU - Kataoka, Kazunori

PY - 2009/7/6

Y1 - 2009/7/6

N2 - Special delivery! Polyionic complex (PIC) micelles that contain the charge-conversional moieties citaconic amide or cis-aconitic amide were developed for cytoplasmic protein delivery. The increase of the charge density on the protein cargo helped the stability of the PIC micelles without cross-linking, and the charge-conversion in endosomes induced the dissociation of the PIC micelles to result in efficient endosomal release (see picture).

AB - Special delivery! Polyionic complex (PIC) micelles that contain the charge-conversional moieties citaconic amide or cis-aconitic amide were developed for cytoplasmic protein delivery. The increase of the charge density on the protein cargo helped the stability of the PIC micelles without cross-linking, and the charge-conversion in endosomes induced the dissociation of the PIC micelles to result in efficient endosomal release (see picture).

KW - Charge conversion

KW - Cytochromes

KW - Drug delivery

KW - Endosomes

KW - Micelles

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U2 - 10.1002/anie.200900064

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ER -

Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm

Abstract

Keywords

ASJC Scopus subject areas

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