Chemical composition and anti-stress effects of yeast hydrolysate

Hyun Sun Lee, Eun Young Jung, Hyung Joo Suh

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


In the present study, the anti-stress effects of yeast hydrolysate (YH) were investigated. The YH consisted of crude carbohydrate (23.6%) and crude protein (68.3%) with low contents of crude ash (3.1%) and crude fat (0.3%). Also, acidic amino acids (glutamic acid+aspartic acid) were present in large quantities (14.2 and 5.0mol%, respectively). Pronase digestion had little effect on the affinity of the YH on 5-hydroxytryptamine (serotonin) and norepinephrine transporters, whereas NaIO4 oxidation of the hydrolysate decreased the affinity by about 10% at 1,000μg/mL, indicating that the periodate-labile carbohydrate moiety played a leading role in the affinity effects of the carbohydrate in YH. As a result of brain mapping after the administration of the YH for 3 days in human subjects, a symmetrical distribution of theta and alpha waves in the central and parietal lobes was observed. This brain mapping pattern of theta and alpha wave distribution appears in a psychologically stable state. The YH groups showed improvements in Beck Depression Inventory and Beck Anxiety Inventory scores after YH administration for 2 weeks. Treatment also seemed to have a more significant (P<.05) impact on the somatic manifestations of anxiety as indexed by the Beck Anxiety Inventory scores. Food materials used as a source of YH have been found to be associated with increases in alertness and adaptation to stress.

Original languageEnglish
Pages (from-to)1281-1285
Number of pages5
JournalJournal of Medicinal Food
Issue number6
Publication statusPublished - 2009 Dec 1


  • Beck anxiety inventory
  • Beck depression inventory
  • Brain mapping
  • Stress

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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